Comparison of Locoregional Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC)
Abstract
:1. Introduction
2. Materials and Methods
3. Results
Mastectomy N = 33 Mean (SD) /N(%) | BCT N = 27 Mean (SD) /N(%) | P Value | |
---|---|---|---|
Age, years | |||
Mean (SD) | 35.61 | 33.15 | 0.04 |
Range | 24–42 | 24–44 | |
Race | |||
Caucasian | 31 (93.9) | 26 (96.3) | 0.65 |
Afro American | 1 (3.1) | 1 (3.7) | |
Other | 1 (3.1) | 0 (0.0) | |
Pregnancy Timing | |||
Antepartum | 15 (45.5) | 16 (59.3) | 0.312 |
Post partum | 18 (54.5) | 11 (40.7) | |
Family History | |||
Positive | 15 (45.5) | 15 (55.6) | 0.031 |
Negative | 11 (33.3) | 12 (44.4) | |
Unknown | 7 (21.2) | 0 (0.0) |
Mastectomy N = 33 N (%) | BCT N = 27 N (%) | P Value | |
---|---|---|---|
BRCA1/2 Mutation | |||
Positive | 3 (37.5) | 4 (50.0) | 0.7 |
Negative | 5 (62.5) | 4 (50.0) | |
ER | |||
Negative | 16 (48.5) | 10 (37.0) | 0.395 |
Positive | 7 (21.2) | 10 (37.0) | |
Unknown | 10 (30.3) | 7 (25.9) | |
Nottingham Grade | |||
1 | 0 (0.0) | 1 (3.7) | 0.05 |
2 | 1 (3.0) | 7 (25.9) | |
3 | 23 (69.7) | 12 (44.4) | |
Unknown | 7 (21.2) | 7 (25.9) | |
LVSI | |||
Absent | 13 (39.4) | 13 (48.1) | 0.720 |
Present | 16 (48.5) | 10 (37.0) | |
Unknown | 4 (12.1) | 4 (14.8) |
Mastectomy N = 33 Mean (SD) /N(%) | BCT N = 27 Mean (SD) /N(%) | P Value | |
---|---|---|---|
Chemotherapy | |||
No | 7 (21.2) | 2 (7.4) | 0.166 |
Yes | 26 (78.8) | 25 (92.6) | |
Neo-Adjuvant Chemotherapy | |||
Yes | 13 (0.50) | 18 (0.72) | 0.08 |
No | 13 (0.50) | 7 (0.28) | |
Type of LN Surgery | |||
ALND | 23 (69.7) | 19 (70.4) | 0.967 |
SLND | 8 (24.2) | 6 (22.2) | |
SLND plus ALND | 2 (6.1) | 2 (2.4) |
Mastectomy N = 33 | BCT N = 27 | P Value | |
---|---|---|---|
Pathological LN Status | |||
Positive | 15 (51.7) | 14 (51.9) | 0.622 |
Negative | 14 (48.3) | 13 (48.1) | |
No. Nodes Dissected | |||
Mean | 12.0 (6.5) | 15.3 (8.4) | 0.099 |
Median | 13 | 15 | |
Range | 1–30 | 2–31 | |
No. Nodes Positive | |||
Mean | 3.6 (5.5) | 0 (1.8) | 0.015 |
Median | 1 | 0 | |
Range | 0–17 | 0–9 | |
T Stage | |||
Tis | 2 (6.1) | 0 (0.0) | 0.006 |
T1 | 6 (18.2) | 13 (48.1) | |
T2 | 11 (33.3) | 14 (51.9) | |
T3 | 8 (24.2) | 0 (0.0) | |
T4 | 3 (9.1) | 0 (0.0) | |
Tx | 3 (9.1) | 0 (0.0) | |
AJCC Stage | |||
0 | 2 (6.1) | 0 (0.0) | 0.077 |
I | 3 (9.1) | 3 (11.1) | |
IIA | 10 (30.3) | 15 (55.6) | |
IIB | 4 (12.1) | 5 (18.5) | |
IIIA | 8 (24.2) | 4 (14.8) | |
IIIC | 6 (18.2) | 0 (0.0) | |
Stage Grouping | |||
0 | 2 (6.1) | 0 (0.0) | 0.044 |
1 | 3 (9.1) | 3 (11.1) | |
2 | 17 (42.4) | 22 (74.1) | |
3 | 17 (42.4) | 2 (14.8) | |
Follow up | |||
Mean (Months) | 51.3 | 61 | 0.401 |
Range | 2–194 | 9.7–164 |
5 yrs (actuarial) | Group 1 % N = 33 (%) | Group 2 % N = 27 (%) | P value |
---|---|---|---|
Locoregional Recurrence | 10 | 37 | 0.04 |
Distant Mets Free | 73 | 81 | 0.68 |
Disease Free Survival | 60 | 71 | 0.52 |
Overall Survival | 57 | 59 | 0.85 |
4. Conclusions
References
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Beriwal, S.; Rungruang, B.; Soran, A.; Thull, D.; Kelley, J.L.; Bhargava, R.; Lin, C.J.; Sukumvanich, P. Comparison of Locoregional Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC). Cancers 2009, 1, 12-20. https://doi.org/10.3390/cancers1010012
Beriwal S, Rungruang B, Soran A, Thull D, Kelley JL, Bhargava R, Lin CJ, Sukumvanich P. Comparison of Locoregional Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC). Cancers. 2009; 1(1):12-20. https://doi.org/10.3390/cancers1010012
Chicago/Turabian StyleBeriwal, Sushil, Bunja Rungruang, Atilla Soran, Darcy Thull, Joseph L. Kelley, Rohit Bhargava, Chyongchiou J. Lin, and Paniti Sukumvanich. 2009. "Comparison of Locoregional Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC)" Cancers 1, no. 1: 12-20. https://doi.org/10.3390/cancers1010012