The Hippo Pathway: Immunity and Cancer
Abstract
:1. Introduction
1.1. Signaling Pathways in Immunology
1.2. Hippo Signaling in Drosophila and Mammals
2. Hippo Signaling Regulates Immune Cell Recruitment and Activation
2.1. Hippo Signaling Modulates the Tumour Microenvironment in Cancer
2.2. The Hippo Pathway Regulates Adaptive Immune Responses
3. Hippo Signaling Is Part of an Immune Response
3.1. Pathogenic Immune Challenges Regulate Hippo Pathway Proteins
3.2. Hippo Signaling Links Immune Responses with Tissue Regeneration
4. Immune Cell-Intrinsic Hippo Signaling
4.1. Clinical Evidence for Immune Cell-Intrinsic Hippo Signaling
4.2. MST1 in the Motility and Trafficking of T Cells
4.3. Hippo Signaling in the Function/Differentiation of T Lymphocytes
4.4. Hippo Signaling in the Immunological Synapse
4.5. Hippo Signaling in Other Leukocytes
4.6. Leukocyte-Intrinsic Hippo Signaling in Cancer
5. Conclusions and Future Directions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Taha, Z.; Janse van Rensburg, H.J.; Yang, X. The Hippo Pathway: Immunity and Cancer. Cancers 2018, 10, 94. https://doi.org/10.3390/cancers10040094
Taha Z, Janse van Rensburg HJ, Yang X. The Hippo Pathway: Immunity and Cancer. Cancers. 2018; 10(4):94. https://doi.org/10.3390/cancers10040094
Chicago/Turabian StyleTaha, Zaid, Helena J. Janse van Rensburg, and Xiaolong Yang. 2018. "The Hippo Pathway: Immunity and Cancer" Cancers 10, no. 4: 94. https://doi.org/10.3390/cancers10040094