Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment
Abstract
:1. Introduction
2. LPLs
2.1. LPA
2.1.1. Increased LPA Levels in EOC
2.1.2. LPA Production and Regulation
2.1.3. Major Cellular Functions and Signaling Mechanisms of LPA in EOC
2.1.4. LPA in the Immune System
2.2. LPC
2.3. Lysophosphatidylinositol (LPI) and Other LPLs
2.4. Sphingosine-1-Phosphate (S1P)
2.4.1. S1P Levels and Production
2.4.2. S1P Functions and Signaling Mechanisms in EOC
2.5. Sphingosylphosphorylcholine (SPC)
3. Conclusions
Funding
Acknowledgments
Conflicts of Interest
References
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Lipid | EOC or BC Plasma | Healthy Control Plasma | EOC Ascites | Benign Ascites |
---|---|---|---|---|
Acyl-LPA | 2–22 [33,34] | 0.6–0.9 [33,34] | 19–95 [28,43] | 2.9 [28,43] |
Alkyl-, and alkenyl-LPA | 3.7 ± 1.7 [28] | 0.9 ± 0.7 [28] | ||
LPI | to 3.0 [28,35] | 0–1.5 [28,35] | 14.7 ± 9.7 [28,35] | 2.9 ± 2.0 [28,35] |
LPC | 120 ± 0.30 [45] 117–153 [34] | 128 ± 46 [45] 122 [34] | ||
S1P | 0.52 ± 0.12 [137] | 0.58 ± 0.18 [45,46,47,48] | sub-µM to low µM [45,46,47,48] | sub-µM to low µM [45,46,47,48] |
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Xu, Y. Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment. Cancers 2018, 10, 227. https://doi.org/10.3390/cancers10070227
Xu Y. Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment. Cancers. 2018; 10(7):227. https://doi.org/10.3390/cancers10070227
Chicago/Turabian StyleXu, Yan. 2018. "Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment" Cancers 10, no. 7: 227. https://doi.org/10.3390/cancers10070227
APA StyleXu, Y. (2018). Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment. Cancers, 10(7), 227. https://doi.org/10.3390/cancers10070227