Cancer Cell Membrane-Coated Nanoparticles for Cancer Management
Abstract
:1. Introduction to Cancer and Nanomedicine
2. Cancer Cell Membrane-Wrapped Nanovehicles
2.1. Multi-step Synthesis of Cell Membrane-Wrapped Nanovehicles
2.1.1. Membrane Extraction
2.1.2. Selection of Nanoparticle Core
2.1.3. Fusion of Membrane Vesicles with Nanoparticle Cores
2.2. Characterization of Membrane-Coated Nanoparticles
3. Applications of Membrane-Wrapped Nanoparticles in Cancer
3.1. Drug Delivery
3.2. Photothermal and Photodynamic Therapy
3.2.1. Combination Photothermal Therapy and Chemotherapy
3.2.2. Photodynamic Therapy Combined with Chemotherapy or Starvation Therapy
3.3. Tumor Imaging
3.4. Immune Stimulation
4. Challenges and Path Forward
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Membrane Source | Core NP Material | Cargo Loaded | Particle Purpose (Besides Homotypic Targeting) | Year | Ref. |
---|---|---|---|---|---|
4T1 | poly(caprolactone); Pluronic F-68 | paclitaxel | drug delivery | 2016 | [40] |
4T1 | gold nanocages | doxorubicin | PTT; hyperthermia-triggered drug release | 2017 | [42] |
4T1 | poly(cyclopentadithiophene-alt-benzothiadiazole) | PTT; PDT; PA imaging | 2018 | [61] | |
4T1 | PCN-224 | tirapazamine | PDT; drug delivery | 2017 | [73] |
MDA-MB-435 | Ln-doped upconversion nanocrystal | FL imaging | 2016 | [54] | |
MDA-MB-435 | PLGA | DiD fluorophore | FL imaging | 2014 | [45] |
Luciferase- expressing MDA-MB-231 | PLGA | FL imaging | 2019 | [43] | |
MCF-7 1 | PLGA | indocyanine green | PTT; PA/FL imaging | 2016 | [74] |
MCF-7 1 | PLGA | doxorubicin; hemoglobin | PDT; drug delivery | 2017 | [63] |
MCF-7 2 | melanin | PTT; PA imaging | 2019 | [68] | |
B16-F10 2 | hollow copper sulfide | doxorubicin | drug delivery | 2018 | [57] |
B16-F10 | mesoporous silica | glucose oxidase | immunotherapy; starvation therapy | 2019 | [55] |
B16-F10 | hollow manganese dioxide | chlorin e6; glucose oxidase | PDT; starvation therapy | 2019 | [67] |
B16-F10 | PLGA | CpG 1826 | Immunotherapy 4 | 2017 | [75] |
B16-F10 | PLGA | monophosphoryl lipid A | Immunotherapy 4 | 2014 | [45] |
B16-OVA 3 | PLGA | imiquimod | Immunotherapy 4 | 2018 | [64] |
HeLa | iron oxide | doxorubicin | drug delivery | 2016 | [44] |
HeLa | PLGA | doxorubicin; siRNA | drug delivery | 2019 | [46] |
HeLa | doxorubicin; indocyanine green | PTT; drug delivery (carrier free) | 2018 | [76] | |
HepG2 | PLGA | doxorubicin | drug delivery | 2019 | [62] |
H22 | iron oxide | doxorubicin | drug delivery | 2016 | [44] |
SMMC-7721 | superparamagnetic iron oxide | chlorin e6 | PDT; MR/NIR imaging | 2018 | [72] |
UM-SCC-7 | iron oxide | doxorubicin | drug delivery | 2016 | [44] |
CAL 27 | Ln-doped upconversion nanocrystal | FL imaging | 2016 | [54] | |
LNCaP-Al | mesoporous silica | doxorubicin; calcium carbonate | drug delivery; pH sensitive release | 2019 | [56] |
DU 145 | Ln-doped upconversion nanocrystal | FL imaging | 2016 | [54] | |
U87 | PLGA | Immunotherapy 4 | 2019 | [43] | |
HCT 116 | Ln-doped upconversion nanocrystal | FL imaging | 2016 | [54] |
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Harris, J.C.; Scully, M.A.; Day, E.S. Cancer Cell Membrane-Coated Nanoparticles for Cancer Management. Cancers 2019, 11, 1836. https://doi.org/10.3390/cancers11121836
Harris JC, Scully MA, Day ES. Cancer Cell Membrane-Coated Nanoparticles for Cancer Management. Cancers. 2019; 11(12):1836. https://doi.org/10.3390/cancers11121836
Chicago/Turabian StyleHarris, Jenna C., Mackenzie A. Scully, and Emily S. Day. 2019. "Cancer Cell Membrane-Coated Nanoparticles for Cancer Management" Cancers 11, no. 12: 1836. https://doi.org/10.3390/cancers11121836
APA StyleHarris, J. C., Scully, M. A., & Day, E. S. (2019). Cancer Cell Membrane-Coated Nanoparticles for Cancer Management. Cancers, 11(12), 1836. https://doi.org/10.3390/cancers11121836