Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion
Abstract
:1. Introduction
2. Mechanisms and Molecular Actors of Tumor Cell Migration and Invasion
2.1. Different Steps of the Migration Process at the Cellular and Molecular Levels
2.1.1. Polarization of the Migrating Cell
2.1.2. Dynamic Interactions of the Migrating Cell with ECM
2.1.3. Cell Contraction and Detachment to ECM Allowing Cell Movement
2.2. Different Cellular Patterns of Migration
2.2.1. Collective Migration
2.2.2. Single Cell Migration/Invasion through a Mesenchymal Mode
2.2.3. Single Cell Migration/Invasion through an Amoeboid Mode
2.3. Migration Strategies Used by Tumor Cells at the Cellular and Molecular Levels
2.3.1. The Metastatic Process in Melanoma
2.3.2. Tumor Migration in Glioblastoma
3. Brief Overview of the Unfolded Protein Response and of the ER Stress Sensors
3.1. UPR Signaling Pathways
3.1.1. Activation Mechanisms of the ER Stress Sensors
3.1.2. ATF6
3.1.3. IRE1
3.1.4. PERK
3.2. Roles of the ER Stress Sensors in Cancer
4. Connections between UPR Signaling and Tumor Cell Migration
4.1. Links between UPR Sensors Activation and Cancer Metastasis
4.2. UPR-Dependent Control of ECM Protein Production and ECM Remodeling
4.2.1. ECM Remodeling by the IRE1/XBP1s Signaling Axis
4.2.2. PERK-Dependent Regulation of MMPs in Cancers
4.2.3. ECM Remodeling upon ATF6 Activation
4.3. Involvement of the UPR-Dependent Secretome in Tumor Migration
4.4. UPR-Mediated Regulation of EMT in Cancers
4.5. UPR-Dependent Regulation of Other Molecular Actors of Tumor Cell Migration
4.5.1. Direct Interaction between IRE1 and Filamin A
4.5.2. HIF1α Regulation by XBP1s
4.5.3. Dual Functions of CREB3L1 Induced by ER Stress on Tumor Migration
4.5.4. LAMP3 Regulation by PERK Signaling in Cancers
5. Conclusions: UPR Signaling and Cell Migration as Future Targets in Cancer Therapy
Funding
Conflicts of Interest
References
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Limia, C.M.; Sauzay, C.; Urra, H.; Hetz, C.; Chevet, E.; Avril, T. Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion. Cancers 2019, 11, 631. https://doi.org/10.3390/cancers11050631
Limia CM, Sauzay C, Urra H, Hetz C, Chevet E, Avril T. Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion. Cancers. 2019; 11(5):631. https://doi.org/10.3390/cancers11050631
Chicago/Turabian StyleLimia, Celia Maria, Chloé Sauzay, Hery Urra, Claudio Hetz, Eric Chevet, and Tony Avril. 2019. "Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion" Cancers 11, no. 5: 631. https://doi.org/10.3390/cancers11050631