Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Sareyeldin, Rasha M.; Gupta, Ishita; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema F.; Vranic, Semir; Al Moustafa, Ala-Eddin

doi:10.3390/cancers11050646

Open AccessReview

Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

by

Rasha M. Sareyeldin

^1,2,

Ishita Gupta

^1,2

,

Israa Al-Hashimi

^1,2,

Hamda A. Al-Thawadi

¹,

Halema F. Al Farsi

¹,

Semir Vranic

^1,*

and

Ala-Eddin Al Moustafa

^1,2,*

¹

College of Medicine, Qatar University, Doha 2713, Qatar

²

Biomedical Research Centre, Qatar University, Doha 2713, Qatar

^*

Authors to whom correspondence should be addressed.

Cancers 2019, 11(5), 646; https://doi.org/10.3390/cancers11050646

Submission received: 26 April 2019 / Revised: 6 May 2019 / Accepted: 8 May 2019 / Published: 10 May 2019

(This article belongs to the Special Issue EGFR in Cancer: Innovative Insights into Signalling, Mutation and Therapeutic Targeting)

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Abstract

Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 (HER2)-enriched (HER2-positive) is characterized by the absence of estrogen and progesterone receptors and overexpression of HER2 receptor, and accounts for 15–20% of all breast cancers. Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. This review focuses on recent advances on gene expression and miRNA status in HER2-positive breast cancer.

Keywords: breast cancer; HER2-positive breast cancer; biomarkers; microarray; gene expression profiling; miRNAs

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MDPI and ACS Style

Sareyeldin, R.M.; Gupta, I.; Al-Hashimi, I.; Al-Thawadi, H.A.; Al Farsi, H.F.; Vranic, S.; Al Moustafa, A.-E. Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer. Cancers 2019, 11, 646. https://doi.org/10.3390/cancers11050646

AMA Style

Sareyeldin RM, Gupta I, Al-Hashimi I, Al-Thawadi HA, Al Farsi HF, Vranic S, Al Moustafa A-E. Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer. Cancers. 2019; 11(5):646. https://doi.org/10.3390/cancers11050646

Chicago/Turabian Style

Sareyeldin, Rasha M., Ishita Gupta, Israa Al-Hashimi, Hamda A. Al-Thawadi, Halema F. Al Farsi, Semir Vranic, and Ala-Eddin Al Moustafa. 2019. "Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer" Cancers 11, no. 5: 646. https://doi.org/10.3390/cancers11050646

APA Style

Sareyeldin, R. M., Gupta, I., Al-Hashimi, I., Al-Thawadi, H. A., Al Farsi, H. F., Vranic, S., & Al Moustafa, A.-E. (2019). Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer. Cancers, 11(5), 646. https://doi.org/10.3390/cancers11050646

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Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

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