Cancer Extracellular Matrix Proteins Regulate Tumour Immunity
Abstract
:Simple Summary
Abstract
1. Introduction
2. Extracellular Matrix Organisation in Healthy Tissue
2.1. Pericellular Membrane (Glycocalyx)
2.2. Basement Membrane
2.3. Interstitial ECM
3. Extracellular Matrix Organisation in Cancer
3.1. Peri-Cellular Membrane
3.2. Basement Membrane
3.3. Interstitial ECM
4. ECM Regulation of Immune Cell Migration
4.1. Structural ECM Proteins
4.2. Non-structural ECM Proteins
5. ECM Regulation of Immune Cell Function
5.1. Myeloid Cells
5.2. T-Lymphocytes, Natural Killer and Dendritic Cells
6. ECM Physics and Tumour Lymphatic Physiology
6.1. Targeting the ECM to Enhance Tumour Immunity
6.2. Renin-Angiotensin Inhibition
6.3. Focal-Adhesion Kinase Inhibition
6.4. Hyaluronan Depletion
6.5. Fibroblast Depletion
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Target | Cancer | Drug | Additional Treatments | Setting | Trial Number | Phase | Primary Outcome/Aim |
---|---|---|---|---|---|---|---|
FAK | Pancreas | Defactinib | PD-1 (Pembrolizumab) | Neoadjuvant and adjuvant | NCT03727880 | 2 | Pathological response |
Lung, mesothelioma, pancreas | Defactinib | PD-1 (Pembrolizumab) | Palliative | NCT02758587 | 1 and 2 | safety | |
Advanced solid cancer | Defactinib | PD-1 (Pembrolizumab), Gemcitabine | Palliative | NCT02546531 | 1 | Dose escalation | |
RAS | Pancreas | losartan | PD-1 (Nivolumab), FOLFIRINOX, SBRT | Neoadjuvant | NCT03563248 | 2 | R0 resection rate |
Hyaluronin | Stomach, lung | PEGPH20 (PEGylated recombinant human hyaluronidase | PD-1 (Pembrolizumab) | Palliative | NCT02563548 | 1 | Safety, dose escalation |
Metastatic pancreas | PEGPH20 | PD-1 (Pembrolizumab) | Palliative | NCT03634332 | 1 | Progression-free survival |
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Gordon-Weeks, A.; Yuzhalin, A.E. Cancer Extracellular Matrix Proteins Regulate Tumour Immunity. Cancers 2020, 12, 3331. https://doi.org/10.3390/cancers12113331
Gordon-Weeks A, Yuzhalin AE. Cancer Extracellular Matrix Proteins Regulate Tumour Immunity. Cancers. 2020; 12(11):3331. https://doi.org/10.3390/cancers12113331
Chicago/Turabian StyleGordon-Weeks, Alex, and Arseniy E. Yuzhalin. 2020. "Cancer Extracellular Matrix Proteins Regulate Tumour Immunity" Cancers 12, no. 11: 3331. https://doi.org/10.3390/cancers12113331
APA StyleGordon-Weeks, A., & Yuzhalin, A. E. (2020). Cancer Extracellular Matrix Proteins Regulate Tumour Immunity. Cancers, 12(11), 3331. https://doi.org/10.3390/cancers12113331