HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristic | All Patients (n = 171) | HEDtotal Low (n = 46) | HEDtotal High (n = 125) | p-Value |
---|---|---|---|---|
Follow-up after HSCT (mo.) | ||||
Median | 59.4 | 51.6 | 62.6 | |
Range | 2.1–173.3 | 2.1–173.3 | 5.5–127.8 | |
Age at Allo-HSCT (yr.) | ||||
Median | 56 | 59 | 55 | 0.30 † |
Range | 21–75 | 21–71 | 22–75 | |
Sex (no. (%)) | ||||
Male | 98 (57.3) | 28 (60.9) | 70 (56.0) | 0.57 ‡ |
Female | 73 (42.7) | 18 (39.1) | 55 (44.0) | |
Karnofsky index (no. (%)) | 0.23 § | |||
≥90 | 115 (67.3) | 31 (67.4) | 84 (67.2) | |
<90 | 35 (20.5) | 12 (26.1) | 23 (18.4) | |
n.a. | 21 (12.3) | 3 (6.5) | 18 (14.4) | |
WHO 2016 subtype (no. (%)) | ||||
RGN | 86 (50.3) | 21 (45.7) | 65 (52.0) | 0.22 § |
MDS-related | 31 (18.1) | 13 (28.3) | 18 (14.4) | |
Therapy-related | 8 (4.7) | 2 (4.3) | 6 (4.8) | |
NOS | 46 (26.9) | 10 (21.7) | 36 (28.8) | |
EBMT risk score (no. (%)) | ||||
1 | 3 (1.8) | 1 (2.2) | 2 (1.6) | 0.23 § |
2 | 28 (16.4) | 6 (13.0) | 22 (17.6) | |
3 | 52 (30.4) | 8 (17.4) | 44 (35.2) | |
4 | 32 (18.7) | 11 (23.9) | 21 (16.8) | |
5 | 38 (22.2) | 14 (30.4) | 24 (19.2) | |
6–7 | 10 (5.8) | 3 (6.5) | 7 (5.6) | |
n.a. | 8 (4.7) | 3 (6.5) | 5 (4.0) | |
ELN risk group ¶ (no. (%)) | ||||
Favorable | 19 (11.1) | 5 (10.9) | 14 (11.2) | 0.81 § |
Intermediate | 110 (64.3) | 32 (69.6) | 78 (62.4) | |
Adverse | 26 (15.2) | 9 (19.6) | 17 (13.6) | |
n.a. | 16 (9.4) | 0 (0.0) | 16 (12.8) | |
HSCT setting (no. (%)) | ||||
1st line consolidation | 106 (62.0) | 25 (54.3) | 81 (64.8) | 0.44 § |
Salvage therapy || | 42 (24.6) | 14 (30.4) | 28 (22.4) | |
Relapse | 23 (13.5) | 7 (15.2) | 16 (12.8) | |
Conditioning regimen (no. (%)) | ||||
FLAMSA | 10 (5.8) | 4 (8.7) | 6 (4.8) | 0.32 § |
FLAMSA-Flu/Bu | 41 (24.0) | 16 (34.8) | 25 (20.0) | |
Flu/TBI | 16 (9.4) | 4 (8.7) | 12 (9.6) | |
Cy/TBI | 19 (11.1) | 3 (6.5) | 16 (12.8) | |
Bu/Cy | 24 (14.0) | 5 (10.9) | 19 (15.2) | |
Flu/BCNU/Mel | 8 (4.7) | 1 (2.2) | 7 (5.6) | |
Flu/Bu | 27 (15.8) | 8 (17.4) | 19 (15.2) | |
Flu/Treosulfan | 18 (10.5) | 2 (4.3) | 16 (12.8) | |
Other | 8 (4.7) | 3 (6.5) | 5 (4.0) | |
Remission at HSCT (no. (%)) | 0.16 § | |||
CR/CRi | 103 (60.2) | 22 (47.8) | 81 (64.8) | |
PR | 23 (13.5) | 8 (17.4) | 15 (12.0) | |
RD | 37 (21.6) | 13 (28.3) | 24 (19.2) | |
n.a. | 8 (4.7) | 3 (6.5) | 5 (4.0) | |
Donor (no. (%)) | ||||
HLA-ident sibling | 63 (36.8) | 23 (50.0) | 40 (32.0) | 0.03 § |
HLA-ident foreign donor | 108 (63.2) | 23 (50.0) | 85 (68.0) |
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Roerden, M.; Nelde, A.; Heitmann, J.S.; Klein, R.; Rammensee, H.-G.; Bethge, W.A.; Walz, J.S. HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation. Cancers 2020, 12, 1835. https://doi.org/10.3390/cancers12071835
Roerden M, Nelde A, Heitmann JS, Klein R, Rammensee H-G, Bethge WA, Walz JS. HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation. Cancers. 2020; 12(7):1835. https://doi.org/10.3390/cancers12071835
Chicago/Turabian StyleRoerden, Malte, Annika Nelde, Jonas S. Heitmann, Reinhild Klein, Hans-Georg Rammensee, Wolfgang A. Bethge, and Juliane S. Walz. 2020. "HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation" Cancers 12, no. 7: 1835. https://doi.org/10.3390/cancers12071835