The Emerging Role of Extracellular Vesicles in the Glioma Microenvironment: Biogenesis and Clinical Relevance
Abstract
:1. Introduction: Extracellular Vesicles and Glioma
2. A Brief Primer on EV Classification, Isolation and Biogenesis
2.1. EV Classification and Isolation
2.2. Small and Medium/Large EVs
2.3. ESCRT-Dependent and ESCRT-Independent Pathways for EV Biogenesis
3. Role of EVs in the ‘Healthy’ Nervous System
3.1. Neural Stem and Progenitor Cell-Derived EVs
3.2. Neuron-Derived EVs
3.3. Astrocyte-Derived EVs
3.4. Oligodendrocyte-Derived EVs
3.5. Microglia-Derived EVs
4. Role of Tumor-Derived EVs in Glioma
4.1. Glioma Subtypes
4.2. EVs in Glioblastomas
4.3. EVs in Oligodendroglioma
5. Clinical Potential of EVs for Glioma: A Non-Invasive Biopsy of the Brain and Its Resident Tumor
5.1. A “Liquid Biopsy” for Glioma: Glioma-Derived EVs as a Biomarker Platform
5.2. Characterization of GBM Subtypes Based on Protein Biomarkers
5.3. Future Directions and Unmet Needs for a GBM “Liquid Biopsy”
5.4. Analysis of EVs on a Single Event Level
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Balakrishnan, A.; Roy, S.; Fleming, T.; Leong, H.S.; Schuurmans, C. The Emerging Role of Extracellular Vesicles in the Glioma Microenvironment: Biogenesis and Clinical Relevance. Cancers 2020, 12, 1964. https://doi.org/10.3390/cancers12071964
Balakrishnan A, Roy S, Fleming T, Leong HS, Schuurmans C. The Emerging Role of Extracellular Vesicles in the Glioma Microenvironment: Biogenesis and Clinical Relevance. Cancers. 2020; 12(7):1964. https://doi.org/10.3390/cancers12071964
Chicago/Turabian StyleBalakrishnan, Anjali, Sabrina Roy, Taylor Fleming, Hon S. Leong, and Carol Schuurmans. 2020. "The Emerging Role of Extracellular Vesicles in the Glioma Microenvironment: Biogenesis and Clinical Relevance" Cancers 12, no. 7: 1964. https://doi.org/10.3390/cancers12071964