Therapeutically Significant MicroRNAs in Primary and Metastatic Brain Malignancies
Abstract
:Simple Summary
Abstract
1. Introduction
2. Brain Cancer
2.1. Primary Brain Cancers
2.2. Brain Metastasis
3. miRNA Biogenesis
miRNA Mechanism of Action
4. miRNAs Differentially Regulated in Brain Cancer
4.1. miR-145
4.2. miR-31
4.3. miR-451
4.4. miR-19a
4.5. miR-143
4.6. miR-125b
4.7. miR-328
4.8. miR-210
4.9. miR-146a
4.10. miR-126
5. miRNA Based Therapeutic Oligonucleotides
6. Conclusions and Prospects
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Names | Total | miRNAs |
---|---|---|
BrM-down BrM-up GBM-down GBM-up | 1 | miR-145 |
BrM-down GBM-down GBM-up | 2 | miR-31 miR-451 |
BrM-up GBM-down GBM-up | 5 | miR-19a miR-143 miR-125b miR-328 miR-210 |
BrM-down BrM-up GBM-down | 2 | miR-146a miR-126 |
GBM-down GBM-up | 31 | miR-221/222 miR-200b miR-132 miR-185 miR-100 miR-135b miR-329 miR-106a miR-873 miR-205 miR-23a miR-323 miR-26b miR-200a miR-30bc miR-330 miR-146 miR-29b miR-9 miR-16 miR-15b miR-195 miR-130a miR-25 miR-23b miR-296 miR-141 miR-29a miR-27a miR-26a miR-107 |
BrM-down GBM-down | 1 | miR-7 |
BrM-up GBM-down | 5 | miR-197 miR-133a miR-378 miR-184 miR-133b |
BrM-down GBM-up | 1 | miR-95 |
BrM-up GBM-up | 2 | miR-21 miR-10b |
GBM-down | 61 | miR-497 miR-429 miR-137 miR-181d miR-129 miR-153 miR-487b miR-340 miR-150 miR-320 miR-339-5p miR-34a miR-491 miR-520b miR-331 miR-101 miR-410 miR-432 miR-181b miR-149 miR-377 miR-190 miR-422a miR-203 miR-124 miR-299 miR-136 miR-485 miR-610 miR-152 miR-146b-5p miR-634 miR-139 miR-219 miR-297 miR-513 LET-7 miR-365a miR-548b miR-181a miR-511-1 miR-218 miR-32 miR-128a miR-885 miR-154 miR-326 miR-433 miR-187 miR-379 miR-519a miR-483 miR-181 miR-874 miR-181c miR-138 miR-663 miR-182 miR-125a miR-148 miR-128 |
GBM-up | 51 | miR-142 miR-204 miR-92a miR-155 miR-20a miR-425 miR-519d miR-28 miR-182/183 miR-10a miR-193 miR-23 miR-93 miR-595 miR-24 miR-140 miR-30a miR-196 miR-148a miR-15a miR-215 miR-96 miR-655 miR-455 miR-196ab miR-130b miR-371-373 miR-18a miR-19b miR-92 miR-486 miR-27b miR-200c miR-301a miR-363 miR-383 miR-134 miR-92b miR-106b miR-123 miR-381 miR-17 miR-27 miR-367-302 miR-339 miR-603 miR-335 miR-372 miR-516-3p miR-17-92 cluster miR-582-5p |
BrM-down | 6 | HS-170 miR-509 miR-1258 miR-30c miR-768-3p miR-29c |
BrM-up | 9 | miR-576-5p miR-1 miR-199b HS-287 miR-200 miR-330-3p miR-28-5p miR-22 miR-199a |
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Balachandran, A.A.; Larcher, L.M.; Chen, S.; Veedu, R.N. Therapeutically Significant MicroRNAs in Primary and Metastatic Brain Malignancies. Cancers 2020, 12, 2534. https://doi.org/10.3390/cancers12092534
Balachandran AA, Larcher LM, Chen S, Veedu RN. Therapeutically Significant MicroRNAs in Primary and Metastatic Brain Malignancies. Cancers. 2020; 12(9):2534. https://doi.org/10.3390/cancers12092534
Chicago/Turabian StyleBalachandran, Akilandeswari A., Leon M. Larcher, Suxiang Chen, and Rakesh N. Veedu. 2020. "Therapeutically Significant MicroRNAs in Primary and Metastatic Brain Malignancies" Cancers 12, no. 9: 2534. https://doi.org/10.3390/cancers12092534