Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Genomic Landscape of RB1 Alterations in Retinoblastoma
2.2. Evidence of Intertumoral Genetic Heterogeneity
2.3. Non-RB1 Alterations in Retinoblastoma
2.4. Copy Number Alterations and Loss of Heterozygosity in Retinoblastoma
3. Discussion
4. Materials and Methods
4.1. Isolation and Purification of DNA
4.2. Exon-Capture Sequencing
4.3. Outside Testing of RB1 Alterations
4.4. Biostatistics
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Francis, J.H.; Richards, A.L.; Mandelker, D.L.; Berger, M.F.; Walsh, M.F.; Dunkel, I.J.; Donoghue, M.T.A.; Abramson, D.H. Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing. Cancers 2021, 13, 149. https://doi.org/10.3390/cancers13010149
Francis JH, Richards AL, Mandelker DL, Berger MF, Walsh MF, Dunkel IJ, Donoghue MTA, Abramson DH. Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing. Cancers. 2021; 13(1):149. https://doi.org/10.3390/cancers13010149
Chicago/Turabian StyleFrancis, Jasmine H., Allison L. Richards, Diana L. Mandelker, Michael F. Berger, Michael F. Walsh, Ira J. Dunkel, Mark T. A. Donoghue, and David H. Abramson. 2021. "Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing" Cancers 13, no. 1: 149. https://doi.org/10.3390/cancers13010149
APA StyleFrancis, J. H., Richards, A. L., Mandelker, D. L., Berger, M. F., Walsh, M. F., Dunkel, I. J., Donoghue, M. T. A., & Abramson, D. H. (2021). Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing. Cancers, 13(1), 149. https://doi.org/10.3390/cancers13010149