Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Fluorescence In Situ Hybridization Patient Cohort
2.2. OncoScan SNP Array Patient Cohort
2.3. SNP Microarray Data Generation and CNA Calling
2.4. Inferring Ancestry
2.5. Statistical Analysis
3. Results
3.1. Genetic Ancestry Inference
3.2. Ancestry-Associated CNA Mutation Density
3.3. Ancestry-Associated CNAs
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Dataset | Europe | Africa | E. Asia | N. American | Mid. East |
---|---|---|---|---|---|
ISUP Grade Group | |||||
1 | 60 | 1 | 3 | 1 | 9 |
2 | 200 | 9 | 6 | 3 | 12 |
3 | 75 | 4 | 2 | 1 | 3 |
4 | 7 | 0 | 0 | 0 | 1 |
5 | 2 | 0 | 0 | 0 | 0 |
NA | 2 | 0 | 0 | 0 | 0 |
Age at Treatment | |||||
40–50 | 7 | 1 | 0 | 1 | 0 |
50–65 | 160 | 4 | 5 | 3 | 8 |
65–70 | 74 | 2 | 1 | 0 | 12 |
≥70 | 105 | 7 | 5 | 1 | 5 |
Pre-treatment PSA | |||||
≤9.9 ng/mL | 4 | 1 | 11 | 3 | 0 |
10–19.9 ng/mL | 93 | 3 | 0 | 1 | 8 |
≥20 ng/mL | 249 | 10 | 0 | 1 | 17 |
T category | |||||
T1 | 165 | 7 | 4 | 4 | 1 |
T2 | 181 | 7 | 7 | 1 | 13 |
T3 | 0 | 0 | 0 | 0 | 11 |
Intraductal carcinoma or cribriform architecture | |||||
Yes | 196 | 3 | 0 | 0 | 21 |
No | 100 | 10 | 9 | 4 | 4 |
NA | 50 | 1 | 2 | 1 | 0 |
Total | 346 | 14 | 11 | 5 | 25 |
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Albawardi, A.; Livingstone, J.; Almarzooqi, S.; Palanisamy, N.; Houlahan, K.E.; Awwad, A.A.A.; Abdelsalam, R.A.; Boutros, P.C.; Bismar, T.A. Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry. Cancers 2021, 13, 2363. https://doi.org/10.3390/cancers13102363
Albawardi A, Livingstone J, Almarzooqi S, Palanisamy N, Houlahan KE, Awwad AAA, Abdelsalam RA, Boutros PC, Bismar TA. Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry. Cancers. 2021; 13(10):2363. https://doi.org/10.3390/cancers13102363
Chicago/Turabian StyleAlbawardi, Alia, Julie Livingstone, Saeeda Almarzooqi, Nallasivam Palanisamy, Kathleen E. Houlahan, Aktham Adnan Ahmad Awwad, Ramy A. Abdelsalam, Paul C. Boutros, and Tarek A. Bismar. 2021. "Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry" Cancers 13, no. 10: 2363. https://doi.org/10.3390/cancers13102363