Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Big and Intriguing Challenge Which May Be Resolved by Integrated Treatments Combining Locoregional and Systemic Therapies
Abstract
:Simple Summary
Abstract
1. Background
2. Salvage Surgery in Patients with Recurrent/Metastatic Disease
3. The Evolving Role of Re-Irradiation (Curative or Palliative Intent)
3.1. Introduction
3.2. RT Schemes Employed in the Clinical Practice for Recurrent/Metastatic Disease
3.3. Palliative Schemes
3.4. Curative Schemes
3.5. The Abscopal Effect
4. Post-Operative Re-Irradiation (+/− Chemotherapy)
5. The Role of Electrochemotherapy
6. The Role of Systemic Strategies (Chemo and Immunotherapy)
7. The Role of Metastasis Directed Therapy (MTD)
8. Discussion and Conclusions
Funding
Conflicts of Interest
References
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Ionna, F.; Bossi, P.; Guida, A.; Alberti, A.; Muto, P.; Salzano, G.; Ottaiano, A.; Maglitto, F.; Leopardo, D.; De Felice, M.; et al. Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Big and Intriguing Challenge Which May Be Resolved by Integrated Treatments Combining Locoregional and Systemic Therapies. Cancers 2021, 13, 2371. https://doi.org/10.3390/cancers13102371
Ionna F, Bossi P, Guida A, Alberti A, Muto P, Salzano G, Ottaiano A, Maglitto F, Leopardo D, De Felice M, et al. Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Big and Intriguing Challenge Which May Be Resolved by Integrated Treatments Combining Locoregional and Systemic Therapies. Cancers. 2021; 13(10):2371. https://doi.org/10.3390/cancers13102371
Chicago/Turabian StyleIonna, Franco, Paolo Bossi, Agostino Guida, Andrea Alberti, Paolo Muto, Giovanni Salzano, Alessandro Ottaiano, Fabio Maglitto, Davide Leopardo, Marco De Felice, and et al. 2021. "Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Big and Intriguing Challenge Which May Be Resolved by Integrated Treatments Combining Locoregional and Systemic Therapies" Cancers 13, no. 10: 2371. https://doi.org/10.3390/cancers13102371