Impact of Previous Irradiation on Wound Healing after Negative Pressure Wound Therapy in Head and Neck Cancer Patients—A Systematic Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Search Findings
2.2. Study Cohort
2.3. NPWT Therapy
2.4. Risk Factors for Delayed Wound Healing
2.5. Quality of Studies
3. Discussion
4. Materials and Methods
4.1. Literature Search or Data Selection
4.2. Data Collection
4.3. Data Analysis and Statistical Methods
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Study Type | Year of Publication | N | Age (in Years) | M:F | Pressure Mode | Negative Pressure | Comorbidity | Previous Irradiation (N) | Healing Response | Complication |
---|---|---|---|---|---|---|---|---|---|---|---|
Andrew [9] | 2006 | Retrospective case series | 12 | 67 | 8:4 | - | 125 | DM *-2 CAD *-2 HTN *-7 Pulmonary disease-7 | 1 | 100 | - |
Andrew [10] | 2008 | Case series | 3 | 67 | 2:1 | - | 150 | 2 | 66 | ||
Asher [11] | 2014 | Retrospective cohort | 108 | 64 | 87:28 | Continuous | 125 | - | 47 | 75 | Bleeding Retained sponge |
Asher [12] | 2014 | Retrospective cohort | 12 | 63 | 6:7 | Continuous | 125 | DM *-4 Hypothyroidism-6 Malnutrition-6 | 9 | 92 | - |
Dhir [13] | 2009 | Retrospective cohort | 19 | 63 | 17:2 | Continuous | 110 | DM *-8 HTN *-16 Malnutrition-9 CAD *-6 PVD *-7 | 10 | 84 | - |
Dorneden [14] | 2019 | Case series | 3 | 66 | 1:2 | Continuous | 125 | - | 0 | 100 | Electrolyte loss |
Inatomi [15] | 2019 | Retrospective cohort | 32 | 63 | 28:6 | - | 125 | - | 14 | 82 | None |
Lin [16] | 2018 | Retrospective series | 31 | 52 | 29:2 | - | 100 | DM *-5 HTN *-6 | 0 | 90 | - |
Reiter [17] | 2013 | Retrospective cohort | 23 | 58 | 12:0 | Continuous | 125 | HTN *-3 | 11 | 78 | None |
Rosenthal [18] | 2005 | Retrospective series | 14 | 59 | 14:5 | Continuous | 125 | - | 0 | 86 | None |
Satteson [19] | 2015 | Retrospective cohort | 69 | 66 | 45:25 | Continuous | - | Smoking-30 HTN *-35 DM *-17 | 36 | 90 | Infection Hematoma Seroma |
Tian [20] | 2016 | Case series | 4 | 55 | 3:1 | - | - | - | 0 | - | None |
Thierauf [21] | 2018 | Retrospective case series | 20 | 8:5 | 70 | DM *-3 PVD *-1 HIV *-1 RA *-1 | 7 | 110 | None | ||
Umezawa [22] | 2018 | Case series | 17 | 67 | 10:1 | - | 6 | 100 | Contact dermatitis | ||
Yang [8] | 2013 | Case series | 13 | 50 | 13:0 | Continuous | 125 | DM *-4 HTN *-2 CVA *-1 | 0 | 92 | None |
Variable | Univariate Analysis | Multivariate Analysis | ||||
---|---|---|---|---|---|---|
OR | p | 95% CI | OR | p | 95% CI | |
Sex (Female) | 2.26 | 0.103 | 0.85–6.0 | 2.01 | 0.223 | 0.66–6.15 |
RT (Yes) | 4.34 | 0.005 | 1.54–11.6 | 4.07 | 0.010 | 1.39–11.9 |
DM (Yes) | 5.65 | <0.001 | 2.14–14.9 | 5.62 | 0.001 | 2.01–15.6 |
RT and DM (Yes) * | 10.6 | <0.001 | 3.38–33.3 | |||
Malnutrition (Yes) | 1.34 | 0.671 | 0.35–5.21 | |||
PVD (Yes) | 1.17 | 0.889 | 0.13–10.2 | |||
Hypothyroidism (Yes) | 0.86 | 0.889 | 0.10–7.52 |
Authors | Study Design | Clear Study Objective | Sample Size Justification | Association/Assessed Levels of Exposure on Outcome | Exposure Defined/Exposure Assessed Repeatedly | Clearly Define Outcome | Clearly Statistic Defined | Follow Up > 80% | Confounding Variables Measured | Rating |
---|---|---|---|---|---|---|---|---|---|---|
Andrew [9] | Retrospective case series | +/+ | + | +/+/+ | +/+ | + | + | + | NR * | Good |
Andrew [10] | Case series | +/+ | NR * | + | +/+ | CD * | + | + | NR * | Fair |
Asher [11] | Retrospective cohort | +/+ | + | +/+/+ | +/+ | + | + | + | + | Good |
Asher [12] | Retrospective cohort | +/+ | + | +/+/+ | +/+ | + | + | + | + | Good |
Dhir [13] | Retrospective cohort | +/+ | + | +/+/+ | +/+ | + | + | + | + | Good |
Dorneden [14] | Case series | + | CD * | +/+/+ | +/+ | CD * | + | + | NR * | Fair |
Inatomi [15] | Retrospective cohort | +/+ | + | +/+/+ | +/+ | + | + | + | + | Good |
Lin [16] | Retrospective series | +/+ | + | +/+/+ | + | + | + | + | CD * | Good |
Reiter [17] | Retrospective cohort | +/+ | + | +/+/+ | + | + | + | + | + | Good |
Rosenthal [18] | Retrospective series | +/+ | + | +/+/+ | + | + | + | + | + | Good |
Satteson [19] | Retrospective cohort | +/+ | + | +/+/+ | + | + | + | + | + | Good |
Tian [20] | Case series | + | CD * | + | + | + | + | + | NR * | Fair |
Thierauf [21] | Retrospective case series | + | + | + | + | + | + | + | + | Good |
Umezawa [22] | Case series | + | + | +/+ | + | + | + | + | CD * | Good |
Yang [8] | Case series | + | + | +/+/+ | + | + | + | + | + | Good |
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Faisal, M.; Berend, P.D.; Seemann, R.; Janik, S.; Grasl, S.; Ritzengruber, A.; Mendel, H.; Jamshed, A.; Hussain, R.; Erovic, B.M. Impact of Previous Irradiation on Wound Healing after Negative Pressure Wound Therapy in Head and Neck Cancer Patients—A Systematic Review. Cancers 2021, 13, 2482. https://doi.org/10.3390/cancers13102482
Faisal M, Berend PD, Seemann R, Janik S, Grasl S, Ritzengruber A, Mendel H, Jamshed A, Hussain R, Erovic BM. Impact of Previous Irradiation on Wound Healing after Negative Pressure Wound Therapy in Head and Neck Cancer Patients—A Systematic Review. Cancers. 2021; 13(10):2482. https://doi.org/10.3390/cancers13102482
Chicago/Turabian StyleFaisal, Muhammad, Peter D. Berend, Rudolf Seemann, Stefan Janik, Stefan Grasl, Andrea Ritzengruber, Herbert Mendel, Arif Jamshed, Raza Hussain, and Boban M. Erovic. 2021. "Impact of Previous Irradiation on Wound Healing after Negative Pressure Wound Therapy in Head and Neck Cancer Patients—A Systematic Review" Cancers 13, no. 10: 2482. https://doi.org/10.3390/cancers13102482