Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Inclusion and Exclusion Criteria
2.2. Search Strategy and Study Selection
2.3. Data Extraction and Synthesis
2.4. Statistical Analysis
3. Results
3.1. Search and Study Selection
3.2. Study Characteristics
3.3. HPV16 E2, E6 and E7 Serology Summary Estimates
3.4. Subgroup Analysis
3.5. Other HPV16 Proteins and Combinatorial Algorithms
3.6. Risk of Bias Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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First Author | Year | n Total | HPV+ (n) | HPV− (n) | Reference Method(s) | Antigen Expression System | HPV16 Antigens 1 | Country of Origin | Time of Collection 2 |
---|---|---|---|---|---|---|---|---|---|
Herrero 3 [26] | 2003 | 137 | 26 | 111 | DNA PCR | bacterial | E6 and/or E7 | Italy, Spain, Ireland, Poland, India, Cuba, Sudan, Canada, Australia | 1996–1999 |
Smeets [27] | 2007 | 13 | 6 | 7 | RT-PCR and DNA PCR | bacterial | E6, E7 | Netherlands | na |
D’Souza 3 [28] | 2010 | 119 | 85 | 34 | DNA ISH | bacterial | E6 and/or E7 | USA | 2000–2006 |
Anderson [29] | 2011 | 21 | 17 | 4 | DNA PCR | in vitro | E7, E1 | USA | na |
Rotnáglová [30] | 2011 | 45 | 27 | 18 | DNA PCR and RT-PCR | bacterial | E6, E7 | Czech Republic | 2001–2007 |
Liang [18] | 2012 | 89 | 35 | 54 | p16 IHC | bacterial | E6 | USA | 1999–2003 |
Anantharaman 4 [31] | 2013 | 119 | 6 | 113 | p16 IHC and DNA PCR | bacterial | E6, E7 | Germany, Greece, Italy, Ireland, UK, Spain, Norway, Czech Republic, Croatia | 2000–2005 |
D’Souza 4 [32] | 2014 | 200 | 119 | 81 5 | p16 IHC and/or ISH 6 | in vitro | E6, E7 | USA | 2009–2013 |
Lopez [33] | 2014 | 91 | 4 | 87 | DNA PCR | bacterial | E6, E7 | Brazil | 1998–2008 |
Anderson 4 [34] | 2015a | 136 | 55 | 81 5 | p16 IHC and/or ISH 6 | in vitro | E6, E7, E1, E2, E4, E5 | USA | 2009–2013 |
Anderson [35] | 2015b | 137 | 111 | 26 5 | DNA PCR | in vitro | E6, E7, E1, E2, E4, E5 | USA | 2006–2008 |
Dahlstrom [36] | 2015 | 114 | 96 | 18 | DNA PCR | in vitro | E6, E7, E1, E2, E4, E5 | USA | 2006–2008 |
Lang Kuhs [37] | 2016 | 10 | 6 | 4 | p16 IHC and ISH | bacterial | E6 | USA | 2003–2006 |
Lang Kuhs [38] | 2017 | 112 | 87 | 25 | p16 IHC and ISH | bacterial | E6, E7, E1, E2, E4 | USA | 2000–2017 |
Dahlstrom [39] | 2017 | 1053 | 271 | 782 5 | p16 IHC and ISH | in vitro | E6, E7, E1, E2, E4, E5 | USA | 2003–2013 |
Broglie [40] | 2017 | 50 | 26 | 24 | p16 IHC and DNA PCR | bacterial | E6, E7, E1, E2, E4 | Switzerland | na |
Holzinger [41] | 2017 | 120 | 66 | 54 | (NASBA or RT-PCR) and DNA PCR | bacterial | E6, E7, E1, E2 | Italy, Germany | na |
Zhang [42] | 2017 | 115 | 115 | - 7 | p16 IHC and/or ISH 6 | bacterial | E6, E7, E1, E2, E4 | USA | 2009–2013 |
Hanna [43] | 2017 | 16 | 16 | - 7 | p16 IHC and (ISH or DNA PCR) | in vitro | E6, E7, E2 | USA | 2013–2015 |
Anantharaman 4 [44] | 2018 | 153 | 49 | 104 | p16 IHC and DNA PCR | bacterial | E6 | Germany, Greece, Italy, Ireland, UK, Spain, Norway, Czech Republic, Croatia | 2002–2005 |
D’Souza [45] | 2019 | 306 | 89 | 217 5 | p16 IHC and/or ISH 6 | bacterial | E6, E7, E1, E2 | USA | 2009–2013 |
Lang Kuhs [46] | 2020 | 46 | 46 | - 7 | p16 IHC | bacterial | E6, E7, E1, E2, E4 | USA | 2017–2018 |
Ren [47] | 2020 | 696 | 524 | 172 | p16 IHC | bacterial | E6 | Canada | na |
Fakhry 4 [48] | 2020 | 146 | 146 | - 7 | p16 IHC and RNA ISH | bacterial | E6, E7 | USA | 2013–2018 |
Windon 4 [49] | 2020 | 220 | 150 | 70 5 | p16 IHC and RNA ISH | bacterial | E6, E7 | USA | 2013–2018 |
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Hibbert, J.; Halec, G.; Baaken, D.; Waterboer, T.; Brenner, N. Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis. Cancers 2021, 13, 3010. https://doi.org/10.3390/cancers13123010
Hibbert J, Halec G, Baaken D, Waterboer T, Brenner N. Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis. Cancers. 2021; 13(12):3010. https://doi.org/10.3390/cancers13123010
Chicago/Turabian StyleHibbert, Julia, Gordana Halec, Dan Baaken, Tim Waterboer, and Nicole Brenner. 2021. "Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis" Cancers 13, no. 12: 3010. https://doi.org/10.3390/cancers13123010
APA StyleHibbert, J., Halec, G., Baaken, D., Waterboer, T., & Brenner, N. (2021). Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis. Cancers, 13(12), 3010. https://doi.org/10.3390/cancers13123010