PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ–DNMT1 Interactions in the Genome
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Identification and Configuration of Repetitive Elements
2.2. Structural Modelling of PPAR-Responsive Element in DNMT1 Promoter Region
2.3. PPARγ and DNMT1 Gene Expression and Mutational Spectrum
2.4. Analysis of Putative PPARγ–DNMT1 Protein–Protein Interactions
2.5. Analysis of PPARγ–DNMT1 in Uveal Melanoma
3. Results
3.1. Distinctive Genomic Architecture of PPREs-Alu Motifs in the Promoter of DNMT1
3.2. PPREs and DNMT1 Interactions
3.3. PPARγ–DNMT1 Cancer Landscape and Protein–Protein Interactions
3.4. PPARγ–DNMT1: Insights from Uveal Melanoma
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Sharma, A.; Tobar-Tosse, F.; Chand Dakal, T.; Liu, H.; Biswas, A.; Menon, A.; Paruchuri, A.; Katsonis, P.; Lichtarge, O.; Gromiha, M.M.; et al. PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ–DNMT1 Interactions in the Genome. Cancers 2021, 13, 3993. https://doi.org/10.3390/cancers13163993
Sharma A, Tobar-Tosse F, Chand Dakal T, Liu H, Biswas A, Menon A, Paruchuri A, Katsonis P, Lichtarge O, Gromiha MM, et al. PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ–DNMT1 Interactions in the Genome. Cancers. 2021; 13(16):3993. https://doi.org/10.3390/cancers13163993
Chicago/Turabian StyleSharma, Amit, Fabian Tobar-Tosse, Tikam Chand Dakal, Hongde Liu, Arijit Biswas, Athira Menon, Anoosha Paruchuri, Panagiotis Katsonis, Olivier Lichtarge, M. Michael Gromiha, and et al. 2021. "PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ–DNMT1 Interactions in the Genome" Cancers 13, no. 16: 3993. https://doi.org/10.3390/cancers13163993