Integrative Transcriptome Profiling Reveals SKA3 as a Novel Prognostic Marker in Non-Muscle Invasive Bladder Cancer

Round 1

Reviewer 1 Report

This manuscript describes  the usefulness SKA3 as prognostic marker for urothelial bladder cancers. Experiments were well conducted. This manuscript was well written and is acceptable for publication at the present form.

Author Response

We are submitting the revised manuscript (cancers-1320924) “Integrative Transcriptome Profiling Reveals SKA3 as a Novel Prognostic Marker in Non-Muscle Invasive Bladder Cancer” by Chaelin You, Xuan-Mei Piao, Keunsoo Kang, Yong-June Kim, and Kyuho Kang, for consideration for publication in Special Issue "Diagnostic and Treatment for Three Urological Cancers: Bladder Cancer, Kidney Cancer and Prostate Cancer" of Cancers. We thank the Reviewers and Editors for their time and encouraging and insightful comments. We are pleased that the Reviewer noted the “Experiments were well conducted.”, “This manuscript was well written and is acceptable for publication at the present form.” We have checked few minor typos and have revised the manuscript. Changes in the manuscript have been highlighted in blue.

We appreciate the Reviewers for their helpful comments. Thank you for considering the revised manuscript for publication in Cancers.

Sincerely,

Kyuho Kang, Ph.D.

Reviewer 2 Report

This is a rather interesting paper about the espression level of SKA3 gene, wich is markedly increased in patients with high progression risk and poor prognosis.

It could become a viable predictive marker for bladder cancer progression.

Author Response

We are submitting the revised manuscript (cancers-1320924) “Integrative Transcriptome Profiling Reveals SKA3 as a Novel Prognostic Marker in Non-Muscle Invasive Bladder Cancer” by Chaelin You, Xuan-Mei Piao, Keunsoo Kang, Yong-June Kim, and Kyuho Kang, for consideration for publication in Special Issue "Diagnostic and Treatment for Three Urological Cancers: Bladder Cancer, Kidney Cancer and Prostate Cancer" of Cancers. We thank the Reviewers and Editors for their time and encouraging and insightful comments. We are pleased that the Reviewer noted the “This is a rather interesting paper about the expression level of SKA3 gene, which is markedly increased in patients with high progression risk and poor prognosis.”, “It could become a viable predictive marker for bladder cancer progression.” We have checked few minor typos and have revised the manuscript. Changes in the manuscript have been highlighted in blue.

We appreciate the Reviewers for their helpful comments. Thank you for considering the revised manuscript for publication in Cancers.

Sincerely,

Kyuho Kang, Ph.D.