Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Definitions
2.3. The Netherlands Cancer Registry
2.4. Statistical Analyses
3. Results
3.1. Differentiated Thyroid Carcinoma (DTC)
3.2. Medullary Thyroid Carcinoma (MTC)
4. Discussion
4.1. Differentiated Thyroid Carcinoma (DTC)
4.2. Medullary Thyroid Carcinoma (MTC)
4.3. Site of Treatment
4.4. Strengths and Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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(A) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Characteristics | Total | Average per Year | Period of Diagnosis | |||||||
1990–1999 | 2000–2009 | 2010–2019 | ||||||||
N | % | N | N | % | N | % | N | % | p-value | |
722 | 24 | 186 | 26 | 223 | 31 | 313 | 43 | |||
Age | 0.75 | |||||||||
0–9 | 13 | 2 | 0 | 4 | 2 | 5 | 2 | 4 | 1 | |
10–14 | 61 | 8 | 2 | 16 | 9 | 18 | 8 | 27 | 9 | |
15–17 | 130 | 18 | 4 | 27 | 15 | 46 | 21 | 57 | 18 | |
18–24 | 518 | 72 | 17 | 139 | 75 | 154 | 69 | 225 | 72 | |
Median age (in years, p25–p75) | 20 | (17–23) | 21 | (17–23) | 20 | (17–23) | 20 | (17–23) | 0.23 | |
Sex | 0.98 | |||||||||
boys | 162 | 22 | 5 | 42 | 23 | 49 | 22 | 71 | 23 | |
girls | 560 | 78 | 19 | 144 | 77 | 174 | 78 | 242 | 77 | |
Histology | 0.002 | |||||||||
papillary carcinoma | 594 | 82 | 20 | 138 | 74 | 185 | 83 | 271 | 87 | |
follicular carcinoma | 128 | 18 | 4 | 48 | 26 | 38 | 17 | 42 | 13 | |
T stage a | <0.001 | |||||||||
1 | 198 | 28 | 7 | 25 | 14 | 64 | 31 | 109 | 35 | |
2 | 292 | 42 | 10 | 101 | 57 | 82 | 39 | 109 | 35 | |
3 | 145 | 21 | 5 | 22 | 13 | 41 | 20 | 82 | 26 | |
4 | 62 | 9 | 2 | 28 | 16 | 22 | 11 | 12 | 4 | |
unknown (3% of total) | 25 | 1 | 10 | 14 | 1 | |||||
N stage a | 0.02 | |||||||||
0 | 379 | 56 | 13 | 98 | 59 | 99 | 48 | 182 | 59 | |
1 | 300 | 44 | 10 | 68 | 41 | 108 | 52 | 124 | 41 | |
unknown (6% of total) | 43 | 1 | 20 | 16 | 7 | |||||
Metastases a | 0.41 | |||||||||
no | 606 | 97 | 20 | 140 | 97 | 161 | 95 | 305 | 97 | |
yes | 20 | 3 | 1 | 4 | 3 | 8 | 5 | 8 | 3 | |
unknown (13% of total) | 96 | 3 | 42 | 54 | 0 | |||||
Thyroid carcinoma as second primary cancer | 0.65 | |||||||||
yes | 18 | 2 | 1 | 6 | 3 | 6 | 3 | 6 | 2 | |
no | 704 | 98 | 23 | 180 | 97 | 217 | 97 | 307 | 98 | |
(B) | ||||||||||
Characteristics | Total | Average per Year | Period of Diagnosis | |||||||
1990–1999 | 2000–2009 | 2010–2019 | ||||||||
N | % | N | N | % | N | % | N | % | p-value | |
114 | 4 | 66 | 58 | 25 | 22 | 23 | 20 | |||
Age | 0.67 | |||||||||
0–17 | 78 | 68 | 3 | 43 | 65 | 18 | 72 | 17 | 74 | |
18–24 | 36 | 32 | 1 | 23 | 35 | 7 | 28 | 6 | 26 | |
Median age (in years, p25–p75) | 13 | (6–19) | 13.5 | (8–19) | 11 | (6–18) | 11 | (3–18) | 0.32 | |
Sex | 0.18 | |||||||||
boys | 55 | 48 | 2 | 35 | 53 | 8 | 32 | 12 | 52 | |
girls | 59 | 52 | 2 | 31 | 47 | 17 | 68 | 11 | 48 | |
T stage a | 0.35 | |||||||||
1 | 83 | 78 | 3 | 48 | 79 | 19 | 83 | 16 | 70 | |
2 | 12 | 11 | 0 | 7 | 11 | 1 | 4 | 4 | 17 | |
3 | 6 | 6 | 0 | 2 | 3 | 1 | 4 | 3 | 13 | |
4 | 6 | 6 | 0 | 4 | 7 | 2 | 9 | 0 | 0 | |
unknown (6% of total) | 7 | 0 | 5 | 2 | 0 | |||||
N stage a | 0.045 | |||||||||
0 | 67 | 72 | 2 | 42 | 82 | 13 | 59 | 12 | 60 | |
1 | 26 | 28 | 1 | 9 | 18 | 9 | 41 | 8 | 40 | |
unknown (18% of total) | 21 | 1 | 15 | 3 | 3 | |||||
Metastases a | 0.84 | |||||||||
Yes | 5 | 6 | 0 | 2 | 5 | 1 | 6 | 2 | 9 | |
no | 75 | 94 | 3 | 37 | 95 | 17 | 94 | 21 | 91 | |
unknown (30% of total) | 34 | 1 | 27 | 7 | 0 |
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Share and Cite
Lebbink, C.A.; van den Broek, M.F.M.; Kwast, A.B.G.; Derikx, J.P.M.; Dierselhuis, M.P.; Kruijff, S.; Links, T.P.; van Trotsenburg, A.S.P.; Valk, G.D.; Vriens, M.R.; et al. Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span. Cancers 2021, 13, 5104. https://doi.org/10.3390/cancers13205104
Lebbink CA, van den Broek MFM, Kwast ABG, Derikx JPM, Dierselhuis MP, Kruijff S, Links TP, van Trotsenburg ASP, Valk GD, Vriens MR, et al. Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span. Cancers. 2021; 13(20):5104. https://doi.org/10.3390/cancers13205104
Chicago/Turabian StyleLebbink, Chantal A., Medard F. M. van den Broek, Annemiek B. G. Kwast, Joep P. M. Derikx, Miranda P. Dierselhuis, Schelto Kruijff, Thera P. Links, A. S. Paul van Trotsenburg, Gerlof D. Valk, Menno R. Vriens, and et al. 2021. "Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span" Cancers 13, no. 20: 5104. https://doi.org/10.3390/cancers13205104