Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Unique and Redundant Roles of NRF2 and NRF1 in Gene Expression
3. Domain Structure of NRF2 and NRF1
4. Contributions of NRF2 and NRF1 to Cancer Malignancy
5. NRF1 and Proteasome Regulation
5.1. O-GlcNAc Reaction
5.2. Role of O-GlcNAc Modification in Cancer
5.3. Molecular Mechanism for the Release of NRF1 from the Endoplasmic Reticulum
5.4. Molecular Mechanism of NRF1 Transactivation in the Nucleus
5.5. NRF1 Regulation by Cellular UDP-GlcNAc through O-GlcNAcylation
5.6. The Proteasome as a Target for Cancer Therapy
5.7. Combination of NRF1 Inhibitors and Proteasome Inhibitors
5.8. Clinical Correlation between OGT and Proteasome Subunit Proteins
5.9. Roles of Other CNC Family Transcription Factors in Cancer
6. Concluding Remarks
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Sekine, H.; Motohashi, H. Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer. Cancers 2021, 13, 541. https://doi.org/10.3390/cancers13030541
Sekine H, Motohashi H. Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer. Cancers. 2021; 13(3):541. https://doi.org/10.3390/cancers13030541
Chicago/Turabian StyleSekine, Hiroki, and Hozumi Motohashi. 2021. "Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer" Cancers 13, no. 3: 541. https://doi.org/10.3390/cancers13030541