CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
Abstract
:Simple Summary
Abstract
1. Introduction
2. Mechanism of CTLA-4 Immune System Inhibition
3. Regulatory T Cells and Anticancer Immunity
3.1. First Insights into Treg Cells
3.2. Inhibitory Effects of Treg Cells on APC
3.3. Conflicting Roles of Treg Cells in Malignant Tumors
3.4. Treg Cells and the Tumor Microenvironment
3.5. Cross-Talk between Treg Cells and the Tumor Microenvironment
3.6. Treg Cells and Nonself Antigens
4. Correlation between Anti-CTLA-4 Treatment and Its Effect on Treg Cells
5. Conclusive Remarks and Future Directions
Author Contributions
Funding
Conflicts of Interest
References
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---|---|---|
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Sobhani, N.; Tardiel-Cyril, D.R.; Davtyan, A.; Generali, D.; Roudi, R.; Li, Y. CTLA-4 in Regulatory T Cells for Cancer Immunotherapy. Cancers 2021, 13, 1440. https://doi.org/10.3390/cancers13061440
Sobhani N, Tardiel-Cyril DR, Davtyan A, Generali D, Roudi R, Li Y. CTLA-4 in Regulatory T Cells for Cancer Immunotherapy. Cancers. 2021; 13(6):1440. https://doi.org/10.3390/cancers13061440
Chicago/Turabian StyleSobhani, Navid, Dana Rae Tardiel-Cyril, Aram Davtyan, Daniele Generali, Raheleh Roudi, and Yong Li. 2021. "CTLA-4 in Regulatory T Cells for Cancer Immunotherapy" Cancers 13, no. 6: 1440. https://doi.org/10.3390/cancers13061440
APA StyleSobhani, N., Tardiel-Cyril, D. R., Davtyan, A., Generali, D., Roudi, R., & Li, Y. (2021). CTLA-4 in Regulatory T Cells for Cancer Immunotherapy. Cancers, 13(6), 1440. https://doi.org/10.3390/cancers13061440