Prediction of Other-Cause Mortality in Older Patients with Breast Cancer Using Comorbidity
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Design and Patients
2.2. Definitions
2.3. Statistical Analysis
3. Results
3.1. Specific Comorbidities
3.2. Charlson Index
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patients | No. (%) |
---|---|
Total | 7511 |
Year of diagnosis | |
2003 | 309 (4.1) |
2004 | 452 (6.0) |
2005 | 548 (7.3) |
2006 | 564 (7.5) |
2007 | 1552 (20.7) |
2008 | 1615 (21.5) |
2009 | 2471 (32.9) |
Age category | |
70–74 years | 3292 (43.8) |
75–79 years | 1778 (23.7) |
≥80 years | 2441 (32.5) |
TNM stage | |
I | 3297 (43.9) |
II | 3259 (43.4) |
III | 944 (12.6) |
Unknown | 11 (0.2) |
Tumor grade | |
1 | 1847 (24.6) |
2 | 3387 (45.1) |
3 | 1803 (24.0) |
Unknown | 474 (6.3) |
Hormone receptor status | |
ER- and/or PR-positive | 6382 (85.0) |
ER- and PR-negative | 968 (12.7) |
Unknown | 180 (2.3) |
Her2 status | |
Positive | 610 (8.0) |
Negative | 5667 (75.1) |
Unknown | 1269 (16.8) |
Type of surgery | |
Mastectomy | 4346 (57.9) |
Breast-conserving surgery | 3165 (42.1) |
Endocrine treatment * | |
Yes | 3584 (56.2) |
No | 2798 (43.8) |
Chemotherapy | |
Yes | 194 (2.6) |
No | 7317 (97.4) |
Comorbidity | No. (%) |
---|---|
Comorbidities included in Charlson index | |
Myocardial infarction | 671 (8.9) |
Congestive heart failure | 216 (2.9) |
Peripheral vascular disease | 216 (2.9) |
Cerebrovascular disease | 545 (7.3) |
Dementia | 164 (2.2) |
Chronic obstructive pulmonary disease | 620 (8.3) |
Connective tissue disease | 212 (2.8) |
Peptic ulcer disease | 128 (1.7) |
Liver disease | 31 (0.4) |
Diabetes without end-organ damage | 1219 (16.2) |
Diabetes with end-organ damage | 162 (2.2) |
Hemiplegia | 16 (0.2) |
Severe chronic renal disease | 12 (0.2) |
Other frequently occurring comorbidities * | |
Hypertension | 2971 (39.6) |
Arrhythmia | 342 (4.6) |
Valvular heart disease | 294 (3.9) |
Thyroid disease | 293 (3.9) |
Venous thromboembolism/pulmonary embolism | 213 (2.8) |
Angina pectoris | 166 (2.2) |
Tuberculosis | 100 (1.3) |
Hypercholesterolemia | 94 (1.3) |
Psychiatric disease (excluding dementia) | 90 (1.2) |
Comorbidity Category | Charlson Index | Comorbidity Count | ||
---|---|---|---|---|
Crude sHR (95% CI) | Age-Adjusted sHR (95% CI) | Crude sHR (95% CI) | Age-Adjusted sHR (95% CI) | |
0 | Referent | Referent | Referent | Referent |
1 | 1.80 (1.59 to 2.03) | 1.69 (1.49 to 1.90) | 1.60 (1.37 to 1.87) | 1.42 (1.21 to 1.65) |
2 | 2.05 (1.76 to 2.39) | 1.80 (1.54 to 2.10) | 2.01 (1.71 to 2.35) | 1.73 (1.48 to 2.03) |
≥3 | 2.96 (2.49 to 3.53) | 2.82 (2.35 to 3.38) | 3.04 (2.60 to 3.56) | 2.45 (2.09 to 2.88) |
Model c-statistic (95% CI) * | 0.58 (0.57 to 0.59) | 0.65 (0.64 to 0.66) | 0.58 (0.58 to 0.59) | 0.64 (0.64 to 0.65) |
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de Boer, A.Z.; Bastiaannet, E.; Putter, H.; Marang-van de Mheen, P.J.; Siesling, S.; de Munck, L.; de Ligt, K.M.; Portielje, J.E.A.; Liefers, G.J.; de Glas, N.A. Prediction of Other-Cause Mortality in Older Patients with Breast Cancer Using Comorbidity. Cancers 2021, 13, 1627. https://doi.org/10.3390/cancers13071627
de Boer AZ, Bastiaannet E, Putter H, Marang-van de Mheen PJ, Siesling S, de Munck L, de Ligt KM, Portielje JEA, Liefers GJ, de Glas NA. Prediction of Other-Cause Mortality in Older Patients with Breast Cancer Using Comorbidity. Cancers. 2021; 13(7):1627. https://doi.org/10.3390/cancers13071627
Chicago/Turabian Stylede Boer, Anna Z., Esther Bastiaannet, Hein Putter, Perla J. Marang-van de Mheen, Sabine Siesling, Linda de Munck, Kelly M. de Ligt, Johanneke E. A. Portielje, Gerrit Jan Liefers, and Nienke A. de Glas. 2021. "Prediction of Other-Cause Mortality in Older Patients with Breast Cancer Using Comorbidity" Cancers 13, no. 7: 1627. https://doi.org/10.3390/cancers13071627