Dose Profile Modulation of Proton Minibeam for Clinical Application
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Monte Carlo Simulation
2.2. Fabrication of Components for pMBRT
2.3. Measurement of Lateral Dose Profiles
2.4. Biological Response to Proton Minibeams
3. Results
3.1. Monte Carlo Simulation
3.1.1. Validation of MC Simulation
3.1.2. Effect of a Diverging Slit on the Lateral Dose Profiles
3.1.3. Effect of MSC Thickness on PVDR
3.1.4. Effect of the Scatterer on PVDR
3.2. Measurement of Lateral and Longitudinal Dose Profiles
3.3. Biological Response to Proton Minibeams
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Kim, M.; Hwang, U.-J.; Park, K.; Kim, D.; Kim, H.S.; Choi, S.H.; Jeong, J.H.; Shin, D.; Lee, S.B.; Kim, J.-Y.; et al. Dose Profile Modulation of Proton Minibeam for Clinical Application. Cancers 2022, 14, 2888. https://doi.org/10.3390/cancers14122888
Kim M, Hwang U-J, Park K, Kim D, Kim HS, Choi SH, Jeong JH, Shin D, Lee SB, Kim J-Y, et al. Dose Profile Modulation of Proton Minibeam for Clinical Application. Cancers. 2022; 14(12):2888. https://doi.org/10.3390/cancers14122888
Chicago/Turabian StyleKim, Myeongsoo, Ui-Jung Hwang, Kyeongyun Park, Dohyeon Kim, Hak Soo Kim, Sang Hyoun Choi, Jong Hwi Jeong, Dongho Shin, Se Byeong Lee, Joo-Young Kim, and et al. 2022. "Dose Profile Modulation of Proton Minibeam for Clinical Application" Cancers 14, no. 12: 2888. https://doi.org/10.3390/cancers14122888