Retrospective Cohort Study of Practical Applications of Paramagnetic Seed Localisation in Breast Carcinoma and Other Malignancies
, Sileny Han 4, Annouschka Laenen 5 and Ann Smeets 1,*Round 1
Reviewer 1 Report
The study is on a current and interesting topic, is presented clearly and with methodological accuracy with precise exposition of first and secondary outcomes. I would like to ask for further clarification on a sentence in the discussion, pg 7 line 233/234, can you better explain this concept and in wich mode the radiological and pathological assessments are different between the centers?
Author Response
Dear reviewer,
Thank you for your feedback. The variability is mostly due to interobserver variability during the radiological or pathological assessment. The sentence has been changed to add this. (see revised manuscript)
Reviewer 2 Report
This manuscript on paramagnetic seed localisation in non-palpable lesions in breast conserving therapy is covering a new technique which is developed to avoid wire-guided localization, however uses the latter nevertheless for placing the seeds correctly in certain cases, which may represent additional preoperative diagnostic effort. Of note, rates of re-operations are considerably low in these two high-volume centers which is related to the use of the new technique of localisation.
However, the manuscript describes a high rate of shaving intraoperatively of 27,04 %, which turned out to be unnecessary in 82,55 % of cases, as the specimen of the shaved margins did not contain any malignant cells. This may be detrimental to cosmetics aspects and therefore this high rate of shaving should be avoided, e.g. by ultrasound-guided surgery.
Congratulations to this well-written manuscript on a new technique of localisation which may contribute to a reduction of re-operations in breast conserving therapy and to targeted axillary dissection after neoadjuvant chemotherapy.
This manuscript merits publication without further amendment.
Author Response
Dear reviewer,
Thank you for your feedback! I We completely agree with your comments regarding shaving intraoperatively.
