Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. STAT3 Structure and Signaling: The Basics
3. Studying STAT3 by Cell Type in KM-LUAD Models
4. Cell-Specific Functions of STAT3 in KM-LUAD
4.1. Lung Epithelium/Tumor Cells
4.2. Cancer-Associated Fibroblasts
4.3. Macrophages
4.4. Neutrophils
4.5. Myeloid-Derived Suppressor Cells
4.6. T Cells
4.7. Dendritic Cells
4.8. Natural Killer Cells
4.9. B Cells
5. STAT3 Inhibition
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Approaches | Examples | Induction Method |
---|---|---|
Tissue-Specific Cre Recombinase | CCSPCre: lung epithelium | |
SPCCre: whole lung rtTA-tetO: dox-inducible | Germline/AdCre | |
LysMCre: myeloid CD4Cre: helper T cell CD19Cre: B cell NCR1Cre: NK cell | Germline/Adoptive Transfer | |
Mutations | KrasLA2/+ KrasLSL-G12D/+ KrasLSL-G12V/+ ±p53lox/lox | Germline/AdCre |
COPD-like Inflammation | NTHi LPS | Nebulization Intranasal |
Cigarette Smoke Elastase | Smoke exposure Intratracheal | |
Carcinogen | NNK Urethane | Intraperitoneal |
Cigarette Smoke eCigarette | Smoke exposure Atomized nicotine | |
Xenograft | Immunocompromised mouse | Orthotopic, subcutaneous, or intravenous |
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Clowers, M.J.; Moghaddam, S.J. Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma. Cancers 2022, 14, 1785. https://doi.org/10.3390/cancers14071785
Clowers MJ, Moghaddam SJ. Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma. Cancers. 2022; 14(7):1785. https://doi.org/10.3390/cancers14071785
Chicago/Turabian StyleClowers, Michael J., and Seyed Javad Moghaddam. 2022. "Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma" Cancers 14, no. 7: 1785. https://doi.org/10.3390/cancers14071785