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Cancers
Volume 15
Issue 3
10.3390/cancers15030584
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Article
Peer-Review Record

The Impact of Surgery on Circulating Malignant Tumour Cells in Oral Squamous Cell Carcinoma

Cancers 2023, 15(3), 584; https://doi.org/10.3390/cancers15030584
by Justin Curtin 1, Peter Thomson 2, Gordon Wong 3, Alfred Lam 1 and Siu-Wai Choi 4,*
Reviewer 1:
Ubai Alsharif
Reviewer 2:
Ikuya Miyamoto
Cancers 2023, 15(3), 584; https://doi.org/10.3390/cancers15030584
Submission received: 4 December 2022 / Revised: 16 January 2023 / Accepted: 16 January 2023 / Published: 18 January 2023
(This article belongs to the Special Issue Circulating and Disseminated Tumor Cells — Novel Approaches and Future Outlook)

Round 1

Reviewer 1 Report

I would like to congratulate you to this well conducted study and I have the following suggestions:

1. Re-design the tables 1 and 2. There is no need or additional information for stratification by gender. 

2. Why is the information on adjuvant RT/RCT and resection margins missing for some patients?!

Further comments:

- Line 125: All "adjuvant" RCT is a post-surgical. This is redundant.

- Looking at Figure 1, I would say that the statistical test for CTC is probabely not significate. I would encourage you to publish the exact number of CTC, CTM and CTEC in your study as an extra table, and redo the statistical testing as this change the main conclusion from your study.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

This article examines perioperative trends in oral cancer surgery with regard to Circulating Malignant Tumour Cells in oral cancer.

The topic is very interesting and we expect to see further developments in the future.

I thought there was not enough description of previous research in the introduction or discussion section. For example, the tumour marker SCC antigen is a commonly used one. However, it is not clear how it differs from this examination. If there is anything known at the moment, it should be described.

There was nothing of much concern regarding the method or results.

In the Discussion section, it would be better to briefly summarise whether this CMTC shows any specific behaviour in oral cancer.

Author Response

Please see the attachment

Author Response File: Author Response.docx

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