Progress toward Better Treatment of Therapy-Related AML

Round 1

Reviewer 1 Report

I find this manuscript to be an excellent review of a significant clinical issue. It is well written and informative for both close participants of the field and for a wider, more general scientific readership. It describes both the etiology of the disease and the (known to date) underlying molecular basis for it. I have learned a good deal from studying it.

I enthusiastically endorse its publication without modification.

Author Response

We would like to express our gratitude for your positive comments. 

Reviewer 2 Report

Cancer chemotherapy/radiotherapy-derived AML comprised a good portion of AML cases. The current manuscript by Kotsiafti et.al. systematically reviewed the etiology, pathophysiology and emerging treatment of tAML. Overall, the article is well-comprised and very comprehensive. It is easy to read and will be of interest to many people in the field. I highly recommend the publication of this manuscript.

Author Response

We would like to express our gratitude for your positive comments. 

Reviewer 3 Report

The development of acute myeloid leukemia following the treatment with  chemotherapy or ionizing radiotherapy is a complicated and important problem. The manuscript "Progress toward better treatment of therapy-related AML" describes  the causes and prognosis of  therapy-related AML  and the choice of different treatments considering the variable genetic backgrounds of patients.  The manuscript is completely within the scope of Cancers. The manuscript is well written and well illustrated. All major issues related to the mechanisms and treatment strategies of AML  are comprehensively described, the cited literature is relevant and modern. In my opinion, this is a high-quality review paper ready for publication.

Author Response

We would like to express our gratitude for your positive comments.