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Open AccessArticle
Progression-Free Survival and Treatment-Free Interval in Head and Neck Cancer with Long-Term Response to Nivolumab: Timing of Active Discontinuation
by
Mioko Matsuo
Mioko Matsuo 1,*,
Muneyuki Masuda
Muneyuki Masuda 2,
Moriyasu Yamauchi
Moriyasu Yamauchi 3,
Kazuki Hashimoto
Kazuki Hashimoto 1,
Ryunosuke Kogo
Ryunosuke Kogo 1,
Masanobu Sato
Masanobu Sato 1,
Shogo Masuda
Shogo Masuda 1 and
Takashi Nakagawa
Takashi Nakagawa 1
1
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
2
Department of Head and Neck Surgery, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan
3
Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Saga University 5-1-1 Nabeshima, Saga 849-8501, Japan
*
Author to whom correspondence should be addressed.
Submission received: 20 June 2024
/
Revised: 8 July 2024
/
Accepted: 10 July 2024
/
Published: 12 July 2024
Simple Summary
This retrospective study aimed to determine the optimal timing of active discontinuation of long-term responders to immune checkpoint inhibitors in patients with recurrent/metastatic head and neck squamous cell carcinoma. We analyzed treatment duration and treatment-free interval (TFI) in 227 nivolumab-treated patients and determined the timing when progression-free survival (PFS) leveled off and when patients discontinued for unplanned reasons (toxicity or patient decision). The 3-year and 6-year PFS was 15.9% and 15.3%, respectively. The PFS curve was completely flat at 3 years. The median time for patients to request discontinuation was 36.8 months, with a median TFI of 15.1 months. The median time for discontinuation due to toxicity was 18.9 months, with a median TFI of 30.6 months. Given that the PFS curve completely leveled off at 3 years and the median time of discontinuation at the patient’s choice was 3 years, we suggest considering treatment completion at 3 years.
Abstract
The optimal timing for actively discontinuing immune checkpoint inhibitor therapy in long-term responders with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) remains unresolved. We conducted a retrospective study of 246 patients with R/M HNSCC treated with nivolumab to determine the optimal timing to actively discontinue nivolumab therapy. We examined the point at which progression-free survival (PFS) plateaued in all cases. We compared the prognosis of 19 (7.7%) ongoing cases and 227 (92.3%) discontinued cases and analyzed treatment duration and treatment-free interval (TFI). The 6-year overall survival was 11.8% (median, 12.1), and the 6-year PFS was 15.3% (median, 3.0). The PFS curve remained stable for 3 years. The median duration of nivolumab treatment was 2.9 months (range 0.03–81.9): Ongoing group, 41.8 (5.6–81.9); Decision group, 36.8 (4.0–70.1); Toxicity group, 30.6 (2.8–64.8); and progressive disease group, 2.0 (0.03–42.9). TFI in the Decision group was 15.1 months (0.6–61.6) and 30.6 months (2.8–64.8) in the Toxicity group. Long-term responses in R/M HNSCC patients treated with nivolumab are rare but gradually increasing. For this patient group, our best estimate of the optimal time to end treatment is 3 years, as the PFS in this study reached a plateau at that timepoint.
Share and Cite
MDPI and ACS Style
Matsuo, M.; Masuda, M.; Yamauchi, M.; Hashimoto, K.; Kogo, R.; Sato, M.; Masuda, S.; Nakagawa, T.
Progression-Free Survival and Treatment-Free Interval in Head and Neck Cancer with Long-Term Response to Nivolumab: Timing of Active Discontinuation. Cancers 2024, 16, 2527.
https://doi.org/10.3390/cancers16142527
AMA Style
Matsuo M, Masuda M, Yamauchi M, Hashimoto K, Kogo R, Sato M, Masuda S, Nakagawa T.
Progression-Free Survival and Treatment-Free Interval in Head and Neck Cancer with Long-Term Response to Nivolumab: Timing of Active Discontinuation. Cancers. 2024; 16(14):2527.
https://doi.org/10.3390/cancers16142527
Chicago/Turabian Style
Matsuo, Mioko, Muneyuki Masuda, Moriyasu Yamauchi, Kazuki Hashimoto, Ryunosuke Kogo, Masanobu Sato, Shogo Masuda, and Takashi Nakagawa.
2024. "Progression-Free Survival and Treatment-Free Interval in Head and Neck Cancer with Long-Term Response to Nivolumab: Timing of Active Discontinuation" Cancers 16, no. 14: 2527.
https://doi.org/10.3390/cancers16142527
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