Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Selection Criteria for Meta-Analysis
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Year | Modality | n | Age (Median) | Male (%) | Tumor Volume (Median, cc) | GTR Rate(%) | Total Dose (Median, Gy (RBE)) | 3y OS (%) | 5y OS (%) | 5y PFS (%) | Brain Necrosis (%) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Hong [16] | 2022 | Proton | 32 | 44 | 46.9 | 100.0 | 74 | 93 | 93 | 65 | 13 | |
Mattke [17] | 2022 | Particle | 147 | 51 | 57.8 | 40.4 | 0.0 | 91 | 85 | 14 | ||
Holtzman [18] | 2021 | Proton | 112 | 52 | 68.8 | 97.3 | 73.8 | 78 | 83 | 4 | ||
Koto [19] | 2020 | Carbon | 34 | 52 | 52.9 | 18.7 | 0.0 | 60.8 | 97 | 93.5 | 65.7 | 50 |
Hottinger [20] | 2020 | Proton | 142 | 42 | 53.5 | 26.3 | 96.5 | 74 | 83 | 70 | ||
Iannalfi [21] | 2020 | Carbon | 65 | 58 | 64.6 | 13 | 0.0 | 70.4 | 90 | 82 | 30 | |
Iannalfi [21] | 2020 | Proton | 70 | 53 | 57.1 | 3.5 | 27.1 | 74 | 93 | 83 | 30 | |
Takagi [22] | 2018 | Particle | 24 | 56 | 41.7 | 17 | 0.0 | 65 | 95 | 86 | 81 | 8 |
Demizu [23] | 2017 | Proton | 53 | 56 | 70 | 86 | 74.6 | 52.8 | ||||
Weber [24] | 2016 | Proton | 151 | 43 | 57.0 | 35.4 | 100.0 | 74 | ||||
McDonald [25] | 2016 | Proton | 39 | 52 | 53.8 | 24.5 | 12.8 | 77.4 | 81.4 | 18 | ||
Hayashi [26] | 2016 | Proton | 19 | 52 | 42.1 | 19 | 42.1 | 78.4 | 94.7 | 83.2 | 16 | |
Grosshans [27] | 2014 | Proton | 10 | 43 | 100.0 | 69.8 | 20 | |||||
Deraniyagala [28] | 2014 | Proton | 33 | 78.8 | 93.9 | 74 | ||||||
Ares [29] | 2009 | Proton | 42 | 42.9 | 73.5 | 62 | 17 | |||||
Weber [30] | 2005 | Proton | 18 | 39 | 16.4 | 74 | ||||||
Igaki [31] | 2004 | Proton | 13 | 61 | 38.5 | 32.9 | 0.0 | 72 | 85 | 72.2 | 42.2 | 15 |
Castro [32] | 1994 | Particle | 53 | 44 | 43.4 | 100.0 | 72 | 93 | 72 | |||
Roy [33] | 2021 | GKRS | 15 | 16 | 88.9 | |||||||
Napieralska [34] | 2021 | SRS/SRT | 23 | 53 | 52.2 | 17 | 21.7 | 52 | 89 | 69 | 43 | |
Cahill [35] | 2021 | GKRS | 15 | 58 | 66.7 | 13 | 73.3 | 20 | 80 | 67 | 0 | |
Hafez [36] | 2019 | GKRS | 12 | 46 | 41.7 | 2.7 | 0.0 | 16 | 0 | |||
Sanusi [37] | 2018 | GKRS | 20 | 47 | 55.0 | 23.07 | 14.8 | 95 | 95 | 50 | 0 | |
Fung [38] | 2018 | Combined | 106 | 56.6 | 25 | 4.8 | 73.8 | 88.3 | 4 | |||
Wang [39] | 2017 | GKRS | 24 | 35 | 50.0 | 15.8 | 0.0 | 30.5 | 42 | |||
Kim [40] | 2017 | IMRT | 14 | 39 | 21.4 | 78.6 | 67 | 92.9 | 92.9 | 0 | ||
Choy [41] | 2016 | SRS/SRT | 42 | 53 | 57.1 | 27.18 | 92.9 | 17.8 | 37 | |||
Ahmed [42] | 2015 | RT | 30 | 40 | 50.0 | 81 | 73 | 31 | ||||
Cho [43] | 2008 | RT | 19 | 37 | 21.1 | 73.7 | 60.2 | 84.6 | 80 | 40 | ||
Noel [44] | 2005 | Combined | 100 | 53 | 60.0 | 23 | 67 | 92 | 80.5 | 1 | ||
Terahara [45] | 1999 | Combined | 115 | 45 | 57.4 | 46 | 68.9 | 88.9 |
Factors | Coefficient | SE | Lower CL | Upper CL | Z Value | p Value |
---|---|---|---|---|---|---|
3-year OS | ||||||
Modality | 0.269 | 0.331 | −0.379 | 0.918 | 0.814 | 0.416 |
Male ratio | −0.010 | 0.020 | −0.049 | 0.029 | −0.509 | 0.611 |
Age | 0.025 | 0.041 | −0.056 | 0.106 | 0.609 | 0.543 |
5-year OS | ||||||
Modality | 0.300 | 0.187 | −0.066 | 0.666 | 1.605 | 0.108 |
Male ratio | 0.009 | 0.011 | −0.012 | 0.030 | 0.819 | 0.413 |
Age | 0.004 | 0.017 | −0.030 | 0.039 | 0.251 | 0.802 |
3-year PFS | ||||||
Modality | 0.441 | 2.713 | −4.876 | 5.758 | 0.163 | 0.871 |
Male ratio | −0.007 | 0.076 | −0.156 | 0.143 | −0.086 | 0.932 |
Age | 0.007 | 0.068 | −0.126 | 0.140 | 0.105 | 0.916 |
5-year PFS | ||||||
Modality | 0.944 | 0.216 | 0.521 | 1.367 | 4.372 | <0.0001 |
Male ratio | −0.011 | 0.010 | −0.031 | 0.009 | −1.066 | 0.287 |
Age | 0.008 | 0.016 | −0.023 | 0.039 | 0.508 | 0.612 |
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Saito, T.; Mizumoto, M.; Oshiro, Y.; Shimizu, S.; Li, Y.; Nakamura, M.; Hosaka, S.; Nakai, K.; Iizumi, T.; Inaba, M.; et al. Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024. Cancers 2024, 16, 2569. https://doi.org/10.3390/cancers16142569
Saito T, Mizumoto M, Oshiro Y, Shimizu S, Li Y, Nakamura M, Hosaka S, Nakai K, Iizumi T, Inaba M, et al. Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024. Cancers. 2024; 16(14):2569. https://doi.org/10.3390/cancers16142569
Chicago/Turabian StyleSaito, Takashi, Masashi Mizumoto, Yoshiko Oshiro, Shosei Shimizu, Yinuo Li, Masatoshi Nakamura, Sho Hosaka, Kei Nakai, Takashi Iizumi, Masako Inaba, and et al. 2024. "Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024" Cancers 16, no. 14: 2569. https://doi.org/10.3390/cancers16142569