Risk Factors for Positive Resection Margins in Breast-Conserving Surgery for Breast Cancer—Retrospective Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
The Limitations of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | No. of Patients | Patients with PRM | No. of Patients with NRM | p Value | OR (95% CI) | |||
---|---|---|---|---|---|---|---|---|
nr. | % | |||||||
1. | Patient’s age | <40 | 11 | 2 | 18.18 | 9 | 0.2017 | 3.037 (0.5686 to 16.22) |
>/=40 | 132 | 9 | 6.8 | 123 | ||||
2. | BMI | <19 | 3 | 0 | 0 | 3 | 0.5433 | 1.132 (0.05232 to 24.485) |
19–24 | 57 | 6 | 10.52 | 51 | referent | |||
>/=25 | 83 | 5 | 6.02 | 78 | 1.835 (0.5319 to 6.333) | |||
3. | Tumor diameter | <15 mm | 61 | 4 | 6.55 | 57 | 0.7588 | 0.7519 (0.2099 to 2.694) |
>/=15 | 82 | 7 | 8.53 | 75 | ||||
4. | Histological type | NST | 116 | 11 | 9.48 | 115 | 0.3946 | referent |
lobular | 5 | 0 | 0 | 5 | 1.199 (0.06219 to 23.118) | |||
others | 13 | 0 | 0 | 13 | 2.943 (0.1639 to 52.865) | |||
5. | Tumor grade | 1 | 56 | 4 | 7.14 | 52 | 0.6187 | referent |
2 | 61 | 6 | 9.8 | 55 | 0.7051 (0.1882 to 2.642) | |||
3 | 26 | 1 | 3.8 | 25 | 1.923 (0.2041 to 18.122) | |||
6. | Molecular profile | A | 44 | 1 | 2.27 | 43 | 0.3129 | referent |
B Her 2+ | 4 | 1 | 25 | 3 | 0.06977 (0.003441 to 1.415) | |||
B Her2- | 49 | 4 | 8.16 | 45 | 0.2615 (0.02809 to 2.436) | |||
Her 2 | 2 | 0 | 0 | 2 | 0.1724 (0.005496 to 5.409) | |||
TN | 6 | 0 | 0 | 6 | 0.4483 (0.01644 to 12.225) | |||
7. | DCIS | yes | 98 | 11 | 11.22 | 87 | 0.0173 | 11.96 (0.6886 to 207.7) |
no | 45 | 0 | 0 | 45 | ||||
8. | Multicentricity | U | 128 | 8 | 6.25 | 120 | 0.0923 | 0.2667 (0.06231 to 1.141) |
M | 15 | 3 | 20 | 12 | ||||
9. | Microcalcifications | yes | 63 | 7 | 11.11 | 56 | 0.1845 | 6.770 (0.3720 to 123.2) |
No | 25 | 0 | 0 | 25 | ||||
10. | Lymphovascular embolus | yes | 55 | 6 | 10.9 | 49 | 0.2993 | 2.490 (0.5921 to 10.47) |
no | 64 | 3 | 4.6 | 61 | ||||
11. | Tumor necrosis | yes | 41 | 5 | 12.19 | 36 | 0.1428 | 3.102 (0.7005 to 13.73) |
no | 70 | 3 | 4.28 | 67 | ||||
12. | Inflammatory infiltrate | yes | 108 | 7 | 6.48 | 101 | 0.4838 | 0.5545 (0.06046 to 5.085) |
no | 9 | 1 | 11.11 | 8 | ||||
13. | Axillary procedure | ALND | 38 | 3 | 7.89 | 35 | 1.0000 | 1.039 (0.2608 to 4.141) |
SLNB | 105 | 8 | 7.61 | 97 | ||||
14. | Axillary lymph nodes | N0 | 101 | 8 | 7.92 | 94 | 1.0000 | 1.106 (0.2787 to 4.392) |
N1 | 42 | 3 | 7.14 | 39 | ||||
15. | Oncoplastic procedure | yes | 63 | 5 | 7.93 | 58 | 1.0000 | 1.063 (0.3089 to 3.659) |
no | 80 | 6 | 7.5 | 74 | ||||
16. | Neoadjuvant chemotherapy | yes | 34 | 9 | 26.47 | 25 | <0.0001 | 19.26 (3.915 to 94.75) |
no | 109 | 2 | 1.83 | 107 |
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Share and Cite
Georgescu, R.; Tutuianu, F.; Bauer, O.; Toganel, A.; Benedek, Z.; Darii, E.; Turdean, S.; Tutuianu Radoi, C. Risk Factors for Positive Resection Margins in Breast-Conserving Surgery for Breast Cancer—Retrospective Analysis. Cancers 2024, 16, 2930. https://doi.org/10.3390/cancers16172930
Georgescu R, Tutuianu F, Bauer O, Toganel A, Benedek Z, Darii E, Turdean S, Tutuianu Radoi C. Risk Factors for Positive Resection Margins in Breast-Conserving Surgery for Breast Cancer—Retrospective Analysis. Cancers. 2024; 16(17):2930. https://doi.org/10.3390/cancers16172930
Chicago/Turabian StyleGeorgescu, Rares, Flavian Tutuianu, Orsolya Bauer, Anca Toganel, Zalan Benedek, Eugeniu Darii, Sabin Turdean, and Cristina Tutuianu Radoi. 2024. "Risk Factors for Positive Resection Margins in Breast-Conserving Surgery for Breast Cancer—Retrospective Analysis" Cancers 16, no. 17: 2930. https://doi.org/10.3390/cancers16172930