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Open AccessReview
Mesenchymal Tumor Management: Integrating Surgical and Non-Surgical Strategies in Different Clinical Scenarios
by
Laura Samà
Laura Samà 1,*,
Giorgia Amy Rodda
Giorgia Amy Rodda 1,2,
Laura Ruspi
Laura Ruspi 1
,
Federico Sicoli
Federico Sicoli 1
,
Vittoria D’Amato
Vittoria D’Amato 1,
Salvatore Lorenzo Renne
Salvatore Lorenzo Renne 2,3,
Alice Laffi
Alice Laffi 4,
Davide Baldaccini
Davide Baldaccini 5,
Elena Clerici
Elena Clerici 5
,
Pierina Navarria
Pierina Navarria 5
,
Marta Scorsetti
Marta Scorsetti 2,5
,
Alexia Francesca Bertuzzi
Alexia Francesca Bertuzzi 4,
Vittorio Lorenzo Quagliuolo
Vittorio Lorenzo Quagliuolo 1 and
Ferdinando Carlo Maria Cananzi
Ferdinando Carlo Maria Cananzi 1,2
1
Sarcoma, Melanoma and Rare Tumors Surgery Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
2
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy
3
Department of Pathology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
4
Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
5
Radiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
*
Author to whom correspondence should be addressed.
Cancers 2024, 16(17), 2965; https://doi.org/10.3390/cancers16172965 (registering DOI)
Submission received: 29 July 2024
/
Revised: 20 August 2024
/
Accepted: 25 August 2024
/
Published: 25 August 2024
Simple Summary
Soft tissue sarcomas (STSs) are rare cancers, making up less than 1% of all adult malignancies. Traditionally, the primary treatment for STS has been surgical resection. However, non-surgical approaches are becoming increasingly important in specific clinical situations. In this review, we explore the role of non-surgical treatments in managing STS, including their use as a bridge to surgery, as alternatives to surgery, for improving surgical outcomes, and for managing cases where surgery is not an option. Our findings highlight the effectiveness of these strategies in enhancing patient care and outcomes, providing a more personalized and less invasive approach to STS treatment. This review aims to advance the understanding and application of non-surgical methods in the treatment of soft tissue sarcomas.
Abstract
Mesenchymal tumors originate from mesenchymal cells and can be either benign or malignant, such as bone, soft tissue, and visceral sarcomas. Surgery is a cornerstone treatment in the management of mesenchymal tumors, often requiring complex procedures performed in high-volume referral centers. However, the COVID-19 pandemic has highlighted this need for alternative non-surgical approaches due to limited access to surgical resources. This review explores the role of non-surgical treatments in different clinical scenarios: for improving surgical outcomes, as a bridge to surgery, as better alternatives to surgery, and for non-curative treatment when surgery is not feasible. We discuss the effectiveness of active surveillance, cryoablation, high-intensity focused ultrasound, and other ablative techniques in managing these tumors. Additionally, we examine the use of tyrosine kinase inhibitors in gastrointestinal stromal tumors and hypofractionated radiotherapy in soft tissue sarcomas. The Sarculator tool is highlighted for its role in stratifying high-risk sarcoma patients and personalizing treatment plans. While surgery remains the mainstay of treatment, integrating advanced non-surgical strategies can enhance therapeutic possibilities and patient care, especially in specific clinical settings with limitations. A multidisciplinary approach in referral centers is vital to determine the optimal treatment course for each patient.
Share and Cite
MDPI and ACS Style
Samà, L.; Rodda, G.A.; Ruspi, L.; Sicoli, F.; D’Amato, V.; Renne, S.L.; Laffi, A.; Baldaccini, D.; Clerici, E.; Navarria, P.;
et al. Mesenchymal Tumor Management: Integrating Surgical and Non-Surgical Strategies in Different Clinical Scenarios. Cancers 2024, 16, 2965.
https://doi.org/10.3390/cancers16172965
AMA Style
Samà L, Rodda GA, Ruspi L, Sicoli F, D’Amato V, Renne SL, Laffi A, Baldaccini D, Clerici E, Navarria P,
et al. Mesenchymal Tumor Management: Integrating Surgical and Non-Surgical Strategies in Different Clinical Scenarios. Cancers. 2024; 16(17):2965.
https://doi.org/10.3390/cancers16172965
Chicago/Turabian Style
Samà, Laura, Giorgia Amy Rodda, Laura Ruspi, Federico Sicoli, Vittoria D’Amato, Salvatore Lorenzo Renne, Alice Laffi, Davide Baldaccini, Elena Clerici, Pierina Navarria,
and et al. 2024. "Mesenchymal Tumor Management: Integrating Surgical and Non-Surgical Strategies in Different Clinical Scenarios" Cancers 16, no. 17: 2965.
https://doi.org/10.3390/cancers16172965
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