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Article

Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021

by
Itunu O. Sokale
1,2,*,
Omar Rosales
1,
Aaron P. Thrift
1,2,
Hashem B. El-Serag
2,3,
Elyse Burgess
1 and
Abiodun O. Oluyomi
1,2,4
1
Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
2
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
3
Section of Gastroenterology and Hepatology and Clinical Epidemiology and Comparative Effectiveness Program in the Health Services Research, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
4
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Cancers 2025, 17(9), 1431; https://doi.org/10.3390/cancers17091431
Submission received: 2 March 2025 / Revised: 7 April 2025 / Accepted: 15 April 2025 / Published: 24 April 2025
(This article belongs to the Section Cancer Epidemiology and Prevention)
Browse Figures
Versions Notes

Simple Summary

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. Current data regarding national HCC disparities may mask important place-based differences in trends. The national HCC incidence rate dropped significantly in recent years from 2018 to 2021, suggesting progress. However, the decrease was not uniform across US geographic divisions and racial/ethnic groups, highlighting the need for additional strategic interventions. Interventions with racial/ethnic- and place-specific considerations may offer practical solutions to HCC disparities.

Abstract

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer diagnoses and deaths in the United States. This study serves as an update on secular trends in national HCC incidence rates while exploring potential geographic and racial/ethnic differences across all nine US census divisions. Methods: We analyzed HCC incidence data reported to the United States Cancer Statistics (USCS) database from 2001 to 2021 (excluding 2020 data, based on the Centers for Disease Control and Prevention’s cautionary recommendations for COVID-19 pandemic data usage for trend analysis). We performed trend analyses of age-adjusted incidence rates in the US overall, by census divisions, and then stratified by race/ethnicity, using the National Cancer Institute’s Joinpoint Regression Program. Results: Between 2001 and 2021, HCC incidence rates increased nationally, with an average annual percentage change (AAPC) of 2.51 (95% confidence interval (CI): 2.32–2.72); however, the rate decreased (annual percentage change (APC) −3.33 (95% CI: −4.78–−1.96) in recent years from 2018 to 2021. Division 1 had the greatest decrease (APC −6.46 (95% CI: −9.62–−3.96) from 2017 to 2021, while rates leveled in Division 6 (East South Central) and Division 7 (West South Central). HCC trends decreased substantially for non-Hispanic Black and Non-Hispanic Asian and Pacific Islander groups in almost all divisions in recent years, but trends were stable, decreased, or increased for other racial/ethnic populations. Conclusions: Despite declining national HCC incidence rates, these trends were not uniform across racial/ethnic groups or US census divisions. Race-specific interventions are needed to reduce disparities in HCC incidence in all US census divisions.

1. Introduction

Primary liver cancer, predominantly hepatocellular carcinoma (HCC), is a major public health issue worldwide. It is the sixth most diagnosed cancer, the third leading cause of cancer-related deaths globally, and the sixth cause of cancer deaths in the US [1]. There are long-standing disparities in HCC burden in the U.S. The reasons for these disparities are multifactorial, but likely include varying prevalences between groups of exposures to known risk factors for HCC, including chronic viral hepatitis (hepatitis B virus or hepatitis C virus), tobacco use, heavy alcohol consumption, obesity, diabetes, and metabolic dysfunction-associated steatotic liver disease (MALSD) [1].
HCC incidence rates have been rising in the US since the early 1980s [2], but recent studies with data through 2019 have suggested a plateau or decline in the trends of overall HCC incidence rates during recent years (2015–2019) [3,4,5]. However, another recent study [6] found racial/ethnic disparities in HCC burden and incidence trends nationally, including incidence data from 2020 in the trend analysis. While findings from these earlier studies are important, there are several gaps in the knowledge. First, analyses at the national level may mask important place-based differences in trends. Therefore, understanding how HCC has impacted specific subgroups in different places in the US over the years is critical for identifying intervention priorities and optimizing resources to mitigate the disease burden and reduce disparities. One available option to study the effect of “place” is census divisions, which are defined as geographic areas containing states with similar historical development, demographic characteristics, and economies [7]. Second, the Centers for Disease Control and Prevention (CDC), in their cautionary recommendations [8], stated that due to cancer data reporting disruptions during the COVID-19 pandemic, using 2020 data may distort joinpoint trend analysis results. Recently, the National cancer Institute updated the Joinpoint program with a feature that allows the exclusion of any data point [9]. Thus, our analysis serves as an update on the overall trends in HCC incidence rates and explores potential geographic and racial/ethnic differences across the nine US census divisions from 2001 to 2021 (excluding 2020 data) following the CDC guidance for data usage [8].

2. Materials and Methods

2.1. Study Design, Data Source, and Study Population

In this cross-sectional study, we analyzed data on HCC cases from the United States Cancer Statistics (USCS) database from 2001 to 2021, which covered 98% of the US population and included 50 states and the District of Columbia. USCS data are contributed by the National Cancer Institute’s (NCI) Surveillance, Epidemiology, and End Results (SEER) program, Centers for Disease Control and Prevention’s (CDC) National Program of Cancer Registries (NPCR), and CDC’s National Vital Statistics System (NVSS) [10]. All data analyzed in this study are de-identified and publicly available, and hence were exempted from review by the institutional review board based on the Policy for the National Human Research Protections Advisory Committee.

2.1.1. Case Definition

HCC cases were identified according to the International Classification of Diseases for Oncology, Third Edition [ICD-O-3], site code C22.0 and histology codes 8170-8175, 8180/2, and 8180/3 [11].

2.1.2. Study Variables

We assessed trends in age-adjusted incidence rates in the US overall, by census divisions, and then stratified by race/ethnicity. Geography was based on the nine U.S. Census Bureau divisions (Figure 1) [12,13]. Race/ethnicity was categorized as Hispanic (all races), non-Hispanic Asian or Pacific Islander, non-Hispanic Black, non-Hispanic White, and non-Hispanic American Indian/Alaska Native. We excluded other racial/ethnic subgroups due to small group sizes.

2.2. Analysis

The USCS database provides incidence rates per 100,000 population, age-adjusted to the 2000 US standard population. Rates were suppressed when the racial/ethnic group had fewer than 16 cases [14]. Joinpoint regression was performed to examine temporal trends in age-standardized incidence rates of HCC using the NCI’s Joinpoint Regression Program version 5.2.0. [15] Joinpoint regression fits a series of joined straight lines on a logarithmic scale to the trends in annual age-adjusted rates by starting with no joinpoint and then determining whether 1 or more joinpoints are required for the best model. If the annual percent change (APC) or average annual percentage change (AAPC) was statistically significantly different from zero, we considered the rates to increase or decrease; otherwise, we reported rates as stable or level. The statistical significance level was defined as a 2-sided p-value < 0.05. Of note, the Joinpoint program was recently updated with a feature that allows the exclusion of any data point. The change was made due to the effect of COVID-19 pandemic disruption on data collection, which may distort joinpoint modeling calculations. The new feature offers the opportunity to exclude potentially biased data points from joinpoint modeling calculations [8]. Thus, we conducted the joinpoint analysis using data from 2001 to 2021, excluding the 2020 dataset.

3. Results

3.1. HCC Incidence Rates, 2001–2021 (2020 Skipped)

The HCC age-adjusted incidence rates from 2001 to 2021 (excluding 2020 data) are presented in Table 1. There were 390,289 individuals diagnosed with HCC in the USCS registry during the study period. The overall national incidence rate was 5.49 per 100,000 population (95% confidence interval (CI): 5.47–5.50) during the study period. However, there were significant regional differences. The highest rate was in Division 7: West South Central (7.26 per 100,000 (95% CI: 7.20–7.32) and the lowest rate was observed in Division 4: West North Central (4.16 per 100,000 (95% CI: 4.10–4.22). For racial/ethnicity groups, the highest rate was found in the non-Hispanic Asian and Pacific Islander group, while the second and third highest rates were in the Hispanic and non-Hispanic American Indian/Alaska Native groups, respectively (Table 1).

3.2. Temporal Trends in HCC Incidence Rates

3.2.1. Temporal Trends in HCC Incidence Rates Overall

The AAPC and APC of the joinpoint regression analyses are displayed in Table 2 and Supplementary Table S1. There was an increase in HCC incidence rates overall (AAPC = 2.51, 95% CI: 2.32–2.72, p < 0.001) from 2001 to 2021. However, the joinpoint analysis for the national trend identified sub trends within the overall time period; it showed that HCC incidence rates increased from 2001 until 2015, stabilized during 2015–2018 (APC = −0.75, 95% CI: −1.31–3.26, p = 0.453), and then decreased by 3% per year from 2018 to 2021 (APC = −3.33, 95% CI: −4.78–−1.96, p < 0.001) (Figure 2).

3.2.2. Temporal Trends in HCC Incidence in US Census Divisions

HCC incidence rates increased across each US census division during the entire study period. However, most divisions have experienced a downward trend in HCC incidence in recent years, except Divisions 6: East South Central (2014–2021: APC = −0.30, 95% CI: −1.08–0.37, p = 0.294) and Division 7: West South Central (2018–2021: APC = −1.85, 95% CI: −3.52–0.52, p = 0.136), where trends leveled (Figure 2). The steepest decreases were observed in Division 1: New England (2017–2021: APC = −6.46, 95% CI: −9.62–−3.96, p < 0.001) and Division 3: East North Central (2018–2021: APC = −4.68, 95% CI: −6.27–−2.78, p < 0.001).

3.2.3. Temporal Trends in HCC Incidence in US Census Divisions by Race and Ethnicity

Joinpoint analyses of census divisions stratified by race and ethnicity are presented in Figure 3A–D and Supplementary Table S1. We found substantial racial/ethnic variations in HCC incidence across US census divisions. For Hispanics, HCC incidence increased in most divisions over the duration of the study, except in Division 1: New England (AAPC = 0.62, 95% CI: −0.34–2.08, p = 0.134) and Division 4: West North Central (AAPC = 1.45, 95% CI: −0.62–4.31, p = 0.149), where the increases were not significant. Temporal changes could not be assessed for non-Hispanic American Indian/Alaska Native individuals in eight of the nine divisions due to small sample sizes. However, in the only available trend (Division 9: Pacific), there was a substantial upsurge in incidence rates throughout the study period for American Indian/Alaska Native individuals (AAPC = 3.92, 95% CI: 2.03–6.60, p < 0.001). For the Non-Hispanic Asian and Pacific Islander group, HCC incidence decreased in many divisions (Divisions 1, 2, 5, 7, 8, and 9) but stabilized in other divisions (Divisions 3, and 4) over time. A joinpoint could not be determined for the group in Division 6: East South Central due to the suppressed small sample size. Among non-Hispanic Black individuals, HCC incidence either increased or leveled across US divisions during the entire study period. For example, rates increased in Divisions 3, 5, 6, and 7 during the entire study period. For non-Hispanic White individuals, HCC incidence rose from 2001 to 2021 across every division, with the largest rise in Division 6: East South Central (AAPC = 5.09, 95% CI: 4.88–5.38, p < 0.001).

3.2.4. Recent Temporal Trends in HCC Incidence in US Census Divisions by Race and Ethnicity

In recent years, joinpoint analyses (Figure 3A–D) indicated downward trends in HCC incidence among multiple racial/ethnic groups across the US census divisions. Among Hispanic populations, there was downward trend in incidence rates in multiple census divisions (1, 2, 8, and 9), while they stabilized in Divisions 4, 5, and 7 and increased in Division 3. For the non-Hispanic American Indian/Alaska Native group in Division 9: Pacific, there was no inflection point, and the rate increased (APC = 3.92, 95% CI: 2.03–6.60, p < 0.001). Among Non-Hispanic Asian and Pacific Islanders, sharp decreases were observed in all divisions except Division 3: East North Central, where rates plateaued (2001–2021: APC = −0.91, 95% CI: −1.99–0.44, p = 0.184) throughout the study period. The greatest rate declines among Non-Hispanic Asian and Pacific Islander populations were seen in Division 1: New England from 2017 to 2021 (APC = −19.24, 95% CI: −32.22–−10.08, p < 0.001). Joinpoint analyses suggested significant slowing in HCC incidence trends in recent years among Non-Hispanic Black populations in every division. We found the highest recent rate declines among Non-Hispanic Black people in Division 4: West North Central from 2016 to 2021 (APC = −11.20, 95% CI: −24.97–−4.43, p = 0.006), followed by Division 2: Middle Atlantic (APC = −9.06, 95% CI: −12.45–−6.90, p < 0.001). Lastly, for the non-Hispanic White group, a substantial downward trend in HCC incidence has occurred in recent years in seven of the nine divisions (starting from 2018 in some of the divisions), but this plateaued in Divisions 6 and 7.

4. Discussion

This temporal trend analysis of HCC incidence rates in the United States found a national increasing trend from 2001 to 2021. However, the trend was not linear. While rates increased rapidly through 2009, the rate of increase has slowed, plateaued, or even reversed (decreased) in recent years. In addition, we found variations across subgroups of the population when the trend analysis was stratified by US census divisions and race/ethnicity. Of note, southern US divisions had higher HCC incidence rates from 2001 to 2021, with Division 6 (East South Central) having the highest rate and AAPC. While the current analysis found decreased rates in most divisions in recent years, rates in the southern divisions remained stable over the period. Furthermore, in recent years, incidence trends have decreased considerably for the non-Hispanic Black and non-Hispanic Asian and Pacific Islander groups in almost all divisions, while they varied (either stabilizing, increasing, or decreasing) for non-Hispanic White and Hispanic populations across US census divisions. Also, in recent years, the rate has increased significantly among the non-Hispanic American Indian/Alaska Native group.
Our national data showing a non-linear upward but slowing trend in HCC incidence over the study period are in contrast with recent studies of non-national (SEER) datasets suggesting a declining or stable trend [3,4,5]. While the reasons for slowing rates of increase, as well as a downtrend in recent years, may be not be completely understood, the changes may be partly due to ongoing HCC interventions, including viral hepatitis prevention (e.g., vaccination (HBV) and screening (HBV and HCV)) [16], antiviral treatment for HCV and HBV, and tobacco cessation programs [17] and treatments [18]. A possible explanation for the observed geographic and racial/ethnic variations in HCC trends may be due to varying levels of exposure to risk factors [19,20,21,22], population characteristics, and inequitable access to prevention or guideline-concordant treatments [23,24]. The shifting landscape of HCC risk factors [25], which impact subgroups differently, may contribute to racial/ethnic and place-based HCC trend variations in the current study. Non-Hispanic Asian or Pacific Islanders were 10 times more at risk for chronic HBV, and non-Hispanic American Indian and Alaskan Natives had twice the risk of HCV than non-Hispanic White individuals [26,27,28]. However, the trend of HBV- and HCV-related HCC incidence and mortality have drastically reduced over the years due to effective preventative measures [26,27,28]. Interventions targeting specific racial/ethnic groups with high burdens of HCC risk factors may have contributed to the observed trend [29].
Notable favorable trends among the non-Hispanic Asian and Pacific Islanders and non-Hispanic Black groups may be due to increased awareness, improved screening uptake, vaccination (HBV), and treatments (HCV and HBV). Despite reducing infection-related (HBV and HCV) HCC incidence, the rapidly rising prevalence of MASLD [30] and alcohol-associated liver diseases are possible drivers of the observed national increasing HCC incidence trends. Moreover, studies have reported increasing mortality from MASLD and alcohol-related liver diseases in the US [31,32,33,34]. Metabolic dysfunctions, e.g., diabetes, obesity, and MASLD, are more prevalent among Hispanic populations compared to other ethnic subgroups [21]. The conditions are challenging to prevent and treat [35], and possibly slow down the rates of HCC incidence decline in this group. The American Indian/Alaskan Native group experiences a disproportionately higher prevalence of alcohol use disorder and MASLD than any other racial group in the US [36,37]. Unfavorable HCC incidence trends in the group may be partly related to the exacerbation of these risks by multilevel stressors, including individual and area-level low SES and structural discrimination, coupled with limited access to coping resources.
Place-based determinants of health across racial/ethnic groups influence cancer risks and incidence. Geographic variation in HCC incidence in the US is well documented [28,38].Population characteristics and healthcare access differences could partly explain US census division disparities in HCC trends. Despite decreasing HCC incidence trends in recent years in most US divisions, rates remained stable in the East South Central (Alabama, Kentucky, Mississippi, and Tennessee) and West South Central (Arkansas, Louisiana, Oklahoma, and Texas) US. Historically, the southern US, in general, has had higher-than-national proportions of Hispanics and low socioeconomic status (SES). The geographic disparities in HCC incidence trends likely represent a constellation of HCC risk factor burden and poor access to preventative services in these divisions [39,40,41,42]. Our data highlight areas of opportunity for targeted HCC prevention. Studies are needed to understand the multilevel determinants contributing to slow progress in HCC prevention, including biological, behavioral, social, environmental, and health system factors. Optimizing risk stratification, availability and access to effective HCC interventions, and pharmacological management, as well as prioritizing inclusiveness, are essential to reducing disparities in HCC incidence. There is a need to develop targeted evidence-based intervention studies within clinical and community settings to increase awareness about HCC risk and prevention, and behaviors to curb emerging modifiable risks, including obesity, MASLD, and alcohol use disorder.

Limitations

This study has important limitations that are worth considering when interpreting our results. First, the USCS data do not provide information on risk factors. Thus, we could not examine the role of specific exposures that may influence HCC incidence. Second, the results of some groups were suppressed due to small sample sizes to minimize the risk of patient confidentiality disclosure. Third, we cannot rule out the possibility of misclassification of race and ethnicity during data collection. Fourth, data for racial/ethnic groups with small sizes (e.g., non-Hispanic American Indian/Alaskan Native) were suppressed for confidentiality reasons, so the interpretation of the groups’ results should be approached with caution due to the possibility of errors arising from missing data. However, the strengths of our study are the use of representative data covering all 50 US states and the District of Columbia, as well as a comprehensive analysis examining trends in smaller geographic units for multiple racial and ethnic groups, unlike recent studies conducted at the national level. For example, our study is the first to report a significant downward trend in HCC incidence among non-Hispanic Black populations in every US census division. Also, while most recent studies have reported declining rates among non-Hispanic Asian and Pacific Islanders in general, we found stabilized rates for those in Division 3 (East North Central).

5. Conclusions

Our data showed a slowing uptrend in HCC incidence nationally. Southern US census divisions had higher incidence rates and a more rapid uptick than other divisions from 2001 to 2021, with the highest rate in Division 6 (East South Central). Unlike other divisions with downward trends over time, trends only leveled in Division 6 (East South Centra) and Division 7 (West South Central). Across US census divisions, the greatest declines in rates were observed among non-Hispanic Asian and Pacific Islanders, followed by non-Hispanic Black. The Non-Hispanic White and Hispanic groups were the least affected by the recent downward trend, while non-Hispanic American Indians/Alaska Natives exhibited an upward trend. Targeted interventions are needed to reduce HCC disparities in the US.

Supplementary Materials

The following supporting information can be downloaded at https://www.mdpi.com/article/10.3390/cancers17091431/s1: Table S1: Trends in HCC incidence rates among US Population by US Census Divisions and Race/Ethnicity, 2001 to 2021 (2020 skipped).

Author Contributions

Conceptualization and design, I.O.S., A.P.T., H.B.E.-S. and A.O.O.; formal analysis, O.R.; data curation, O.R. and E.B.; interpretation of data: I.O.S., A.P.T., H.B.E.-S. and A.O.O.; writing—original draft preparation, I.O.S.; writing—review and editing, all authors; visualization, O.R. and I.O.S.; supervision, A.O.O.; project administration and technical and material support, A.O.O. All authors have read and agreed to the published version of the manuscript.

Funding

This research was supported in part by the Cancer Prevention and Research Institute of Texas (RP150587, RP220119, RP190641 to HES, and RP200537 to APT) and the NCI (NCI P01 CA263025 to HES). AOO’s effort was supported in part by the Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) program NIH OT2OD032581 (PI: Jamboor). AOO and APT’s efforts were supported in part by the facilities and resources of the Gulf Coast Center for Precision and Environmental Health NIH P30ES030285 (PI: Walker) and Texas Medical Center Digestive Disease Center NIH P30DK056338 (PI: El-Serag).

Institutional Review Board Statement

All data analyzed in this study are de-identified and publicly available and were exempted from review by the institutional review board based on the Policy for the National Human Research Protections Advisory Committee.

Informed Consent Statement

Not applicable.

Data Availability Statement

The data used in the current study are de-identified and publicly available and can be requested and obtained from the USCS website.

Conflicts of Interest

The authors declare no conflicts of interest.

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Figure 1. The nine US Census Bureau divisions. Footnote: US census divisions—Division 1: New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont), Division 2: Middle Atlantic (New Jersey, New York, and Pennsylvania), Division 3: East North Central (Illinois, Indiana, Michigan, Ohio, and Wisconsin), Division 4: West North Central (Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, and South Dakota), Division 5: South Atlantic (Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, Washington D.C., and West Virginia), Division 6: East South Central (Alabama, Kentucky, Mississippi, and Tennessee), Division 7: West South Central (Arkansas, Louisiana, Oklahoma, and Texas), Division 8: Mountain (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming), and Division 9: Pacific (Alaska, California, Hawaii, Oregon, and Washington).
Figure 1. The nine US Census Bureau divisions. Footnote: US census divisions—Division 1: New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont), Division 2: Middle Atlantic (New Jersey, New York, and Pennsylvania), Division 3: East North Central (Illinois, Indiana, Michigan, Ohio, and Wisconsin), Division 4: West North Central (Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, and South Dakota), Division 5: South Atlantic (Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, Washington D.C., and West Virginia), Division 6: East South Central (Alabama, Kentucky, Mississippi, and Tennessee), Division 7: West South Central (Arkansas, Louisiana, Oklahoma, and Texas), Division 8: Mountain (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming), and Division 9: Pacific (Alaska, California, Hawaii, Oregon, and Washington).
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Figure 2. Trends in HCC age-adjusted incidence rates by US census geographic divisions, 2001–2021. Footnotes: y axis: age-standardized incidence rate per 100,000. * Indicates that the Annual Percent Change (APC) is significantly different from zero at the alpha = 0.05 level. Abbreviations: APC, annual percent change; Div, US census division. Trend analyses did not include 2020 data because the Centers for Disease Control and Prevention (CDC), in their cautionary recommendations [8], stated that due to cancer data reporting disruptions during the COVID-19 pandemic, using 2020 data may distort joinpoint trend analysis results. APC 1, 2, and 3 represent temporal joinpoint segments based on annual percent changes in age-adjusted HCC incidence rates. US census divisions—Division 1: New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont), Division 2: Middle Atlantic (New Jersey, New York, and Pennsylvania), Division 3: East North Central (Illinois, Indiana, Michigan, Ohio, and Wisconsin), Division 4: West North Central (Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, and South Dakota), Division 5: South Atlantic (Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, Washington D.C., and West Virginia), Division 6: East South Central (Alabama, Kentucky, Mississippi, and Tennessee), Division 7: West South Central (Arkansas, Louisiana, Oklahoma, and Texas), Division 8: Mountain (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming), and Division 9: Pacific (Alaska, California, Hawaii, Oregon, and Washington).
Figure 2. Trends in HCC age-adjusted incidence rates by US census geographic divisions, 2001–2021. Footnotes: y axis: age-standardized incidence rate per 100,000. * Indicates that the Annual Percent Change (APC) is significantly different from zero at the alpha = 0.05 level. Abbreviations: APC, annual percent change; Div, US census division. Trend analyses did not include 2020 data because the Centers for Disease Control and Prevention (CDC), in their cautionary recommendations [8], stated that due to cancer data reporting disruptions during the COVID-19 pandemic, using 2020 data may distort joinpoint trend analysis results. APC 1, 2, and 3 represent temporal joinpoint segments based on annual percent changes in age-adjusted HCC incidence rates. US census divisions—Division 1: New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont), Division 2: Middle Atlantic (New Jersey, New York, and Pennsylvania), Division 3: East North Central (Illinois, Indiana, Michigan, Ohio, and Wisconsin), Division 4: West North Central (Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, and South Dakota), Division 5: South Atlantic (Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, Washington D.C., and West Virginia), Division 6: East South Central (Alabama, Kentucky, Mississippi, and Tennessee), Division 7: West South Central (Arkansas, Louisiana, Oklahoma, and Texas), Division 8: Mountain (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming), and Division 9: Pacific (Alaska, California, Hawaii, Oregon, and Washington).
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Cancers 17 01431 g003aCancers 17 01431 g003b
Figure 3. (A–D) Trends in HCC age-adjusted incidence rates by US census divisions and by race/ethnicity, 2001–2021. Footnotes: y axis: age-standardized incidence rate per 100,000. * Indicates that the Annual Percent Change (APC) is significantly different from zero at the alpha = 0.05 level. Abbreviations: APC, annual percent change; Div, US census division. Trend analyses did not include 2020 data because the Centers for Disease Control and Prevention (CDC), in their cautionary recommendations [8], stated that due to cancer data reporting disruptions during the COVID-19 pandemic, using 2020 data may distort joinpoint trend analysis results. APC 1, 2, and 3 represent temporal joinpoint segments based on annual percent changes in age-adjusted HCC incidence rates. US census divisions—Division 1: New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont), Division 2: Middle Atlantic (New Jersey, New York, and Pennsylvania), Division 3: East North Central (Illinois, Indiana, Michigan, Ohio, and Wisconsin), Division 4: West North Central (Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, and South Dakota), Division 5: South Atlantic (Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, Washington D.C., and West Virginia), Division 6: East South Central (Alabama, Kentucky, Mississippi, and Tennessee), Division 7: West South Central (Arkansas, Louisiana, Oklahoma, and Texas), Division 8: Mountain (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming), and Division 9: Pacific (Alaska, California, Hawaii, Oregon, and Washington).
Figure 3. (A–D) Trends in HCC age-adjusted incidence rates by US census divisions and by race/ethnicity, 2001–2021. Footnotes: y axis: age-standardized incidence rate per 100,000. * Indicates that the Annual Percent Change (APC) is significantly different from zero at the alpha = 0.05 level. Abbreviations: APC, annual percent change; Div, US census division. Trend analyses did not include 2020 data because the Centers for Disease Control and Prevention (CDC), in their cautionary recommendations [8], stated that due to cancer data reporting disruptions during the COVID-19 pandemic, using 2020 data may distort joinpoint trend analysis results. APC 1, 2, and 3 represent temporal joinpoint segments based on annual percent changes in age-adjusted HCC incidence rates. US census divisions—Division 1: New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont), Division 2: Middle Atlantic (New Jersey, New York, and Pennsylvania), Division 3: East North Central (Illinois, Indiana, Michigan, Ohio, and Wisconsin), Division 4: West North Central (Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, and South Dakota), Division 5: South Atlantic (Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, Washington D.C., and West Virginia), Division 6: East South Central (Alabama, Kentucky, Mississippi, and Tennessee), Division 7: West South Central (Arkansas, Louisiana, Oklahoma, and Texas), Division 8: Mountain (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming), and Division 9: Pacific (Alaska, California, Hawaii, Oregon, and Washington).
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Table 1. HCC age-adjusted incidence rates for US population by census divisions, sex, and race/ethnicity, 2001–2021.
Table 1. HCC age-adjusted incidence rates for US population by census divisions, sex, and race/ethnicity, 2001–2021.
PopulationAge-Adjusted Incidence Rate (95% CI)Count (n)
National (50 States and District of Columbia)5.49 (5.47 to 5.50)390,289
US Census Divisions
   Division 1: New England 5.02 (4.95–5.1)17,923
   Division 2: Middle Atlantic 5.69 (5.64–5.74)56,391
   Division 3: East North Central 4.55 (4.51–4.59)49,227
   Division 4: West North Central 4.16 (4.1–4.22)20,045
   Division 5: South Atlantic 5 (4.96–5.03)72,464
   Division 6: East South Central 4.79 (4.72–4.86)20,611
   Division 7: West South Central 7.26 (7.2–7.32)55,060
   Division 8: Mountain 4.91 (4.84–4.97)23,825
   Division 9: Pacific 6.95 (6.9–7.0)74,743
Race and Ethnicity
   Hispanic (All Races)10.21 (10.12–10.29)63,039
   Non-Hispanic American Indian/Alaska Native9.46 (9.17–9.76)4326
   Non-Hispanic Asian or Pacific Islander10.66 (10.54–10.78)32,203
   Non-Hispanic Black7.68 (7.61–7.74)57,874
   Non-Hispanic White4.29 (4.27–4.31)231,319
   Non-Hispanic Unknown Race~1528
Sex
   Female2.40 (2.38 to 2.42)90,797
   Male9.03 (9.00 to 9.06)299,492
Age
   <50 years0.66 (0.65–0.67)27,443
   50+ years18.13 (18.07–18.19)362,846
Table 2. Trends in HCC incidence rates among US population overall and by US census divisions, 2001 to 2021.
Table 2. Trends in HCC incidence rates among US population overall and by US census divisions, 2001 to 2021.
PopulationJoinpoint SegmentAPC (95% CI)pYear 2001–2021p
Year StartYear EndAAPC (95% CI)
Overall
200120095.72 (4.56–6.59)<0.0012.51 (2.32–2.72)<0.001
200920152.95 (2.39–6.77)<0.001
20152018−0.75 (−1.31–3.26)0.453
20182021−3.33 (−4.78–−1.96)<0.001
Division 1: New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, Vermont)
200120086.64 (5.17–9.39)<0.0011.50 (1.02–2.00)<0.001
200820171.27 (0.16–2.36)0.034
20172021−6.46 (−9.62–−3.96)<0.001
Division 2: Middle Atlantic (New Jersey, New York, Pennsylvania)
200120075.19 (2.87–8.06)<0.0011.30 (1.04–1.58)<0.001
200720132.52 (1.48–6.95)<0.001
20132016−0.21 (−2.54–2.75)0.961
20162021−3.69 (−5.36–−2.75)<0.001
Division 3: East North Central (Illinois, Indiana, Michigan, Ohio, Wisconsin)
200120105.68 (5.20–6.31)<0.0012.63 (2.40–2.85)<0.001
201020182.10 (1.65–2.59)<0.001
20182021−4.68 (−6.27–−2.78)<0.001
Division 4: West North Central (Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, South Dakota)
200120126.56 (5.91–9.74)0.0013.64 (3.19–4.20)<0.001
201220173.36 (1.12–5.69)0.008
20172021−3.65 (−7.00–−1.54)0.005
Division 5: South Atlantic (Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, Washington D.C., West Virginia)
200120087.42 (6.62–8.72)<0.0013.40 (3.18–3.67)<0.001
200820154.09 (3.10–4.74)<0.001
20152021−1.87 (−2.69–−1.11)<0.001
Division 6: East South Central (Alabama, Kentucky, Mississippi, Tennessee)
200120079.27 (8.01–11.94)<0.0014.71 (4.47–5.06)<0.001
200720146.04 (4.65–6.86)0.002
20142021−0.30 (−1.08–0.37)0.294
Division 7: West South Central (Arkansas, Louisiana, Oklahoma, Texas)
200120145.11 (3.48–6.78)0.0043.40 (3.14–3.76)<0.001
201420181.94 (0.77–5.93)0.003
20182021−1.85 (−3.52–0.52)0.136
Division 8: Mountain (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, Wyoming)
200120154.69 (4.04–5.54)<0.0012.30 (1.80–2.83)<0.001
20152021−3.07 (−5.74–−1.32)0.002
Division 9: Pacific (Alaska, California, Hawaii, Oregon, Washington)
200120094.86 (4.05–6.77)0.0011.38 (1.05–1.73)<0.001
200920151.39 (−0.42–2.93)0.096
20152021−3.10 (−4.96–−2.07)<0.001
Abbreviations: HCC, hepatocellular carcinoma; APC, annual percentage change; and AAPC, average annual percentage change. Trend analyses did not include 2020 data because the Centers for Disease Control and Prevention (CDC), in their cautionary recommendations [8], stated that due to cancer data reporting disruptions during the COVID-19 pandemic, using 2020 data may distort joinpoint trend analysis results.
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Sokale, I.O.; Rosales, O.; Thrift, A.P.; El-Serag, H.B.; Burgess, E.; Oluyomi, A.O. Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021. Cancers 2025, 17, 1431. https://doi.org/10.3390/cancers17091431

AMA Style

Sokale IO, Rosales O, Thrift AP, El-Serag HB, Burgess E, Oluyomi AO. Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021. Cancers. 2025; 17(9):1431. https://doi.org/10.3390/cancers17091431

Chicago/Turabian Style

Sokale, Itunu O., Omar Rosales, Aaron P. Thrift, Hashem B. El-Serag, Elyse Burgess, and Abiodun O. Oluyomi. 2025. "Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021" Cancers 17, no. 9: 1431. https://doi.org/10.3390/cancers17091431

APA Style

Sokale, I. O., Rosales, O., Thrift, A. P., El-Serag, H. B., Burgess, E., & Oluyomi, A. O. (2025). Differences in Hepatocellular Carcinoma Incidence Trends Across US Census Divisions, 2001 to 2021. Cancers, 17(9), 1431. https://doi.org/10.3390/cancers17091431

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