Therapeutic Targeting of Hyaluronan in the Tumor Stroma
Abstract
:Abbreviation
BRCA1 | breast cancer 1 |
BSA | bovine serum albumin |
CD44 | cluster of differentiation 44 |
Col1α1 | collagen, type 1, alpha 1 |
Col5α1 | collagen, type 5, alpha 1 |
CS | chondroitin sulfate |
DS | dermatan sulfate |
ECM | extracellular matrix |
EGF | epidermal growth factor |
ERK1/2 | extracellular signal-regulated kinase 1/2 |
ERM | ezrin-radixin-moesin |
FAK | focal adhesion kinase |
GFP | green fluorescent protein |
HABP | hyaluronan binding protein |
GPI | glycosylphosphatidylinositol |
GTPase | guanosine triphosphatase |
HA | hyaluronan |
HAS | hyaluronan synthase |
hdf | heart defect |
HER | human epidermal growth factor receptor |
HS | heparan sulfate |
HYAL | hyaluronidase |
HYALP-1 | hyaluronidase pseudogene 1 |
IαI | inter-α-inhibitor |
KPC | LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre |
MAPK | mitogen-activated protein kinase |
NSCLC | non-small cell lung cancer |
PDA | pancreatic ductal adenocarcinoma |
PDGFR | platelet-derived growth factor receptor |
PEG | polyethylene glycol |
PEGPH20 | pegylated human recombinant PH20 hyaluronidase enzyme |
PLN | para-aortic lymph node |
PI3K | phosphoinositide 3-kinase |
RHAMM | receptor for hyaluronan-mediated motility |
rHuPH20 | recombinant human PH20 hyaluronidase |
RTK | receptor tyrosine kinase |
SEM | standard error of the mean |
SHAP | serum-derived hyaluronan-associated protein |
SPAM-1 | sperm adhesion molecule-1 |
Stab2 | stabilin-2 |
tIFP | tumor interstitial fluid pressure |
TGFβR | transforming growth factor beta receptor |
TGI | tumor growth inhibition |
TLR | toll-like receptor |
TNC | tenascin-C |
TNF-α | tumor necrosis factor-alpha |
TSG-6 | tumor necrosis factor-inducible gene 6 protein |
UDP | uridine 5' diphosphate |
VEGF-A | vascular endothelial growth factor A |
1. Introduction—The Tumor Stroma
2. Hyaluronan (HA)
3. The Role of Hyaluronan in the Tumor Stroma
4. The HA Interactome in Cancer
4.1. HA Interactions with ECM Components
4.2. HA Interactions with Cell Surface Receptors
5. Significance of HA Accumulation in Cancer and the Early History of Hyaluronidase Therapies
6. Preclinical Proof of Concept for Therapeutic Targeting of HA in the Tumor Stroma
7. Enzymatic Targeting of Tumor HA
8. Combining Therapeutic Targeting of Tumor HA with Chemotherapy
Treatment 1 | n | Median Survival (days) | Increase in Survival 2 (%) |
---|---|---|---|
Vehicle | 7 | 10.5 | 0 |
Gemcitabine | 11 | 15.0 | 43 |
PEGPH20 | 10 | 9.0 | 0 |
Gemcitabine + PEGPH20 | 11 | 28.5 | 271 |
9. Endogenous Hyaluronidases and HA Oligosaccharides as Tumor Promotors or Suppressors
9.1. Endogenous Hyaluronidase Activity
9.2. HA Oligosaccharides in Cancer
10. Therapeutic Targeting of Tumor HA and Metastasis
11. Conclusions
Acknowledgments
References
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Kultti, A.; Li, X.; Jiang, P.; Thompson, C.B.; Frost, G.I.; Shepard, H.M. Therapeutic Targeting of Hyaluronan in the Tumor Stroma. Cancers 2012, 4, 873-903. https://doi.org/10.3390/cancers4030873
Kultti A, Li X, Jiang P, Thompson CB, Frost GI, Shepard HM. Therapeutic Targeting of Hyaluronan in the Tumor Stroma. Cancers. 2012; 4(3):873-903. https://doi.org/10.3390/cancers4030873
Chicago/Turabian StyleKultti, Anne, Xiaoming Li, Ping Jiang, Curtis B. Thompson, Gregory I. Frost, and H. Michael Shepard. 2012. "Therapeutic Targeting of Hyaluronan in the Tumor Stroma" Cancers 4, no. 3: 873-903. https://doi.org/10.3390/cancers4030873