Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis
Abstract
:1. Introduction
2. Results
2.1. BHA Suppresses Tobacco Smoke Carcinogen (NNK)-Induced Lung Tumorigenesis
2.2. BHA Blocks NNK-Induced Occurrence of F4/80+ Macrophages in Lungs
2.3. BHA Blocks NNK-Induced Increase of Macrophages in BALF
2.4. BHA Specifically Blocks the NNK-Induced Occurrence of TAMs in Lungs
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Reagents and Antibody
4.3. Western Blot Analysis
4.4. NNK-Induced Lung Tumor Models
4.5. Evaluation of Lung Tumors
4.6. Immunohistochemical Analysis
4.7. BALF Leukocyte Counts
4.8. Statistical Analysis
5. Conclusions
Acknowledgments
Conflicts of Interest
References
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Zhang, Y.; Choksi, S.; Liu, Z.-G. Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis. Cancers 2013, 5, 1643-1654. https://doi.org/10.3390/cancers5041643
Zhang Y, Choksi S, Liu Z-G. Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis. Cancers. 2013; 5(4):1643-1654. https://doi.org/10.3390/cancers5041643
Chicago/Turabian StyleZhang, Yan, Swati Choksi, and Zheng-Gang Liu. 2013. "Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis" Cancers 5, no. 4: 1643-1654. https://doi.org/10.3390/cancers5041643