Tobacco Exposure and Complications in Conservative Laryngeal Surgery
Abstract
:1. Introduction
2. Experimental
Characteristics | Aspects | Number of Patients (535) |
---|---|---|
Age group | <60 years | 285 (53%) |
≥ 60 years | 250 (47%) | |
Smoking status | Non smokers | 28 (5%) |
Smokers | 507 (95%) | |
Alcohol consumption | No alcohol consumption | 281 (52%) |
Alcohol abuse | 254 (48%) | |
Tumor subsite | Glottic tumor | 154 (30%) |
Supraglottic tumor | 372 (69%) | |
Transglottic tumor | 9 (1%) | |
cT * classification | 1 | 251 (48%) |
2 | 227 (42%) | |
3 | 41 (7%) | |
4 | 16 (3%) | |
cN ** classification | 0 | 433 (80%) |
1 | 73 (14%) | |
2 | 27 (5.6%) | |
3 | 2 (0.4%) |
Features | Aspects | Number of Patients | ||
---|---|---|---|---|
All patients (n = 535) | Primary PL * (n = 516) | Salvage PL * (n = 19) | ||
Type | Frontolateral | 82 (15%) | 82 (16%) | 0 (0%) |
CHP ** | 105 (20%) | 92 (18%) | 13 (68%) | |
CHEP *** | 39 (7%) | 33 (6%) | 6 (32%) | |
SHL ʃ | 309 (58%) | 309 (60%) | 0 (0) | |
Neck dissection | No | 282 (53%) | 265 (51%) | 17 (89%) |
Yes | 253 (47%) | 251 (49%) | 2 (11%) | |
Type of neck dissection | None | 282 (53%) | 265 (51%) | 17 (90%) |
SND ʃ ʃ | 48 (9%) | 47 (9%) | 1 (5%) | |
mRND ʃ ʃ ʃ | 205 (38%) | 204 (40%) | 1 (5%) |
3. Results and Discussion
Complication | Number of Patients | ||||
---|---|---|---|---|---|
All Patients (n = 535) | Primary PL * (n = 516) | Salvage PL * (n = 19) | p value | ||
Overall | No | 375 (70%) | 359 (70%) | 16 (84%) | 0.61 |
Yes | 160 (30%) | 157 (30%) | 3 (16%) | ||
Local | No | 502 (94%) | 483 (94%) | 19 (100%) | 1.0 |
Yes | 33 (6%) | 33 (6%) | 0 (0%) | ||
Swallowing | No | 496 (93%) | 479 (93%) | 17 (89%) | 0.68 |
Yes | 39 (7%) | 37 (7%) | 2 (11%) | ||
Airway | No | 462 (86%) | 443 (86%) | 19 (100%) | 0.34 |
Yes | 73 (14%) | 73 (14%) | 0 (0%) | ||
Fistula | No | 520 (97%) | 502 (97%) | 18 (95%) | 0.48 |
Yes | 15 (3%) | 14 (3%) | 1 (5%) |
Characteristics | Aspects | Patients (n = 535) | Complicated | Univariate | Multivariate |
---|---|---|---|---|---|
p value | p value | ||||
Age | <60 years | 285 (53%) | 19 (7%) | 0.719 | 0.845 |
>=60 years | 250 (47%) | 14 (6%) | |||
Smoking status | Non smokers | 28 (5%) | 1 (3.57%) | 0.05 | 0.04 |
Smokers | 507 (95%) | 32 (6.3%) | |||
Alcohol consumption | No alcohol | 281 (52%) | 11 (4%) | 0.03 | 0.03 |
Alcohol abuse | 254 (48%) | 22 (9%) | |||
Tumor Site | Supraglottic | 372 (69%) | 27 (7%) | 0.123 | 0.09 |
Glottic | 154 (30%) | 6 (4%) | |||
Transglottic | 9 (1%) | 0 (0%) | |||
cT * | 1 | 253 (48%) | 13 (5%) | 0.705 | 0.962 |
2 | 226 (42%) | 16 (7%) | |||
3 | 40 (7%) | 3 (7%) | |||
4 | 16 (3%) | 1 (6%) | |||
cN ** | 0 | 433 (80%) | 24 (6%) | 0.078 | 0.160 |
1 | 73 (14%) | 5 (7%) | |||
2 | 27 (5.6%) | 3 (10%) | |||
3 | 2 (0.4) | 1 (50%) | |||
Surgery type | Frontolateral | 82 (15%) | 2 (2%) | 0.277 | 0.069 |
CHP ʃ | 106 (20%) | 9 (9%) | |||
CHEP ʃ ʃ | 38 (7%) | 4 (11%) | |||
SHL ʃ ʃ ʃ | 309 (58%) | 18 (6%) | |||
Previous RT *** | No | 516 (96%) | 33 (6%) | 1.000 | 0.981 |
Yes | 19 (4%) | 0 (4%) |
Characteristics | Aspects | Patients (n = 535) | Complicated | Univariate | Multivariate |
---|---|---|---|---|---|
p value | p value | ||||
Age | <60 years | 285 (53%) | 9 (3%) | 0.794 | 0.711 |
>=60 years | 250 (47%) | 6 (2%) | |||
Smoking status | Non smokers | 28 (5%) | 0 (0%) | 0.01 | 0.03 |
Smokers | 507 (95%) | 15 (2.96%) | |||
Alcohol consumption | No alcohol | 281 (52%) | 5 (2%) | 0.189 | 0.124 |
Alcohol abuse | 254 (48%) | 10 (4%) | |||
Tumor Site | Supraglottic | 372 (69%) | 12 (3%) | 0.570 | 0.132 |
Glottic | 163 (30%) | 3 (2%) | |||
cT * | Transglottic | 9 (1%) | 0 (0%) | ||
1 | 253 (48%) | 6 (2%) | 0.901 | 0.612 | |
2 | 226 (42%) | 8 (4%) | |||
3 | 40 (7%) | 1 (2%) | |||
4 | 16 (3%) | 0 (0%) | |||
cN ** | 0 | 433 (80%) | 13 (3%) | 0.075 | 0.923 |
1 | 73 (14%) | 1 (1%) | |||
2 | 27 (5.6%) | 0 (0%) | |||
3 | 2 (0.4%) | 1 (50%) | |||
Surgery type | Frontolateral | 82 (15%) | 1 (1%) | 0.556 | 0.319 |
CHP ʃ | 106 (20%) | 4 (4%) | |||
CHEP ʃ ʃ | 38 (7%) | 2 (5%) | |||
SHL ʃ ʃ ʃ | 309 (58%) | 8 (3%) | |||
Previous RT *** | No | 516 (96%) | 14 (3%) | 0.351 | 0.519 |
Yes | 19 (4%) | 1 (5%) |
4. Conclusions
Author Contributions
Conflicts of Interest
References
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Fiorini, F.R.; Deganello, A.; Larotonda, G.; Mannelli, G.; Gallo, O. Tobacco Exposure and Complications in Conservative Laryngeal Surgery. Cancers 2014, 6, 1727-1735. https://doi.org/10.3390/cancers6031727
Fiorini FR, Deganello A, Larotonda G, Mannelli G, Gallo O. Tobacco Exposure and Complications in Conservative Laryngeal Surgery. Cancers. 2014; 6(3):1727-1735. https://doi.org/10.3390/cancers6031727
Chicago/Turabian StyleFiorini, Francesca Romana, Alberto Deganello, Guglielmo Larotonda, Giuditta Mannelli, and Oreste Gallo. 2014. "Tobacco Exposure and Complications in Conservative Laryngeal Surgery" Cancers 6, no. 3: 1727-1735. https://doi.org/10.3390/cancers6031727