Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics
Abstract
:1. Introduction
1.1. Nucleic Acid Aptamers and Their Selection Process
1.2. Therapeutic and Diagnostic Applications of Nucleic Acid Aptamers
1.3. Aptamer-Sensing Systems Based on Fluorescence
1.4. Aim of This Review
2. Aptamer-Based Fluorescent Systems for the Specific Recognition of Cancer-Related Targets
2.1. Thrombin
2.2. PDGF
2.3. Angiogenin
2.4. Mucin 1
2.5. VEGF
2.6. Elastase
2.7. PTK7
2.8. Lysozyme
2.9. Cancer Cells
3. Conclusions
Acknowledgments
Conflicts of Interest
References
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Target | Labelling Method | Fluorophore a/Quencher b | Fluorescent Dye c | Mode | Sample | Limit of Detection | Reference |
---|---|---|---|---|---|---|---|
Thrombin | Label-free | -- | Ir(III) complex | Signal-ON | serum, urine, saliva | 0.05 pM | [97] |
Label-free | -- | hemin | Signal-ON | buffer solution | 1 pM | [109] | |
Label-free | -- | SYBR Gold | Signal-ON | serum | 680 nM | [110] | |
Covalent | 6-carboxyfluorescein/dabcyl | -- | Signal-OFF | buffer solution | 112 pM | [98] | |
Covalent | dansyl/β-cyclodextrin | -- | Signal-ON | buffer solution | n.d. | [99] | |
Covalent | fluorescein/dabcyl | -- | Signal-ON | buffer solution | 0.2 μM | [102] | |
Covalent | fluorescein/dabcyl | -- | Signal-ON | buffer solution | 3 μM | [103] | |
Covalent | pyrrolo dC | --- | Signal-ON | buffer solution | 10 μM | [70] | |
Covalent | 6-carboxyfluorescein/Iowa Black FQ | -- | Signal-OFF | buffer solution | 10 μM | [70] | |
Covalent | 6-carboxytetramethylrhodamine/AuNP | -- | Signal-ON | buffer solution | 0.14 nM | [104] | |
Covalent | Cy3/AuNP | Signal-ON | buffer solution | 10 pM | [105] | ||
Covalent | 6-carboxyfluorescein/SWCT | -- | Signal-ON | buffer solution | 1.8 nM | [106] | |
Covalent | 6-carboxyfluorescein/nano-C60 | -- | Signal-ON | serum | 1 nM | [107] | |
Covalent | 6-carboxyfluorescein/graphene | -- | Signal-ON | serum | 31.3 pM | [68] | |
Covalent | Cy3/MNP | -- | Signal-ON | serum | 0.5 nM | [108] | |
Covalent | Quantum dots/dabcyl | -- | Signal-ON | buffer solution | 1 μM | [111] | |
Covalent | fluorescein/dabcyl | -- | Signal-OFF | cell extracts, plasma | 1 nM | [112] | |
Covalent | 6-carboxyfluorescein/ Black Hole Quencher 1 | -- | Signal-ON | serum | 100 pM | [113] | |
PDGF | Label-free | -- | NMM | Signal-ON | serum | 3.2 nM | [114] |
Label-free | -- | TOTO | Signal-OFF | buffer solution | 100 pM | [115] | |
Label-free | -- | TOTO | Signal-OFF | buffer solution | 5 pM | [116] | |
Label-free | -- | SYBR Green I | Signal-ON | serum | 1.25 pM | [117] | |
Covalent | 6-amino fluorescein/dabcyl | -- | Signal-OFF | serum, cell culture media | 110 pM | [118] | |
Covalent | fluorescein/graphene oxide | -- | Signal-ON | serum | 167 pM | [119] | |
Covalent | pyrene | -- | Fluorescence emission shift | cell culture media | pM range | [120] | |
Covalent | fluorescein | -- | Fluorescence anisotropy increase | buffer solution | 220 pM | [121] | |
Covalent | tetramethylrhodamine | -- | Fluorescence anisotropy decrease | buffer solution | pM range | [122] | |
Covalent | fluorescein/dabcyl | -- | Signal-OFF | cell culture media | pM range | [123] | |
Angiogenin | Label free | -- | Alexa Fluor 488 | Fluorescence anisotropy increase | buffer solution | 6.3 nM | [124] |
Covalent | fluorescein | -- | Fluorescence anisotropy increase | serum | 1 nM | [125] | |
Covalent | 6-carboxyfluorescein/6-carboxytetramethyl-rhodamine | -- | Signal-ON | serum | 200 pM | [126] | |
Covalent | Cy5 | -- | Signal-ON | cell culture media | n.d. | [127] | |
Mucin | Label-free | -- | fluorescein | Signal-ON | serum | 3.33 pM | [128] |
Covalent | Cy5/graphene oxide | -- | Signal-ON | serum | 28 nM | [129] | |
Covalent | Cy3 | -- | Signal-ON | cell culture media | n.d. | [130] | |
Covalent | MPA | -- | Signal-ON | cell culture media, nude mice | n.d. | [131] | |
VEGF | Label-free | -- | 6-carboxyfluorescein | Signal-ON | serum | 3.5 pg/mL | [132] |
Covalent | fluorescein | -- | Signal-ON | buffer solution | 1 pM | [133] | |
Covalent | fluorescein | -- | Signal-ON | buffer solution | 25 nM | [134] | |
Covalent | 6-carboxyfluorescein | -- | Fluorescence anisotropy increase | buffer solution | 320 pM | [135] | |
Covalent | 6-carboxyfluorescein | -- | Signal-ON | serum | 250 pM | [136] | |
Elastase | Covalent | fluorescein | -- | Signal-ON | cell culture media, rats | n.d. | [137] |
Covalent | -- | fluorescein | Signal-ON | buffer solution | 47 pM | [138] | |
PTK7 | Label-free | -- | Cy5 | Signal-ON | cell culture media | 1 pM | [139] |
Covalent | Alexa Fluor 647 | -- | Signal-ON | cell culture media, nude mice | n.d. | [140] | |
Lysozyme | Label-free | -- | 6-carboxyfluorescein | Signal-ON | saliva | 200 pM | [141] |
Label-free | -- | 6-carboxyfluorescein | Signal-ON | buffer solution | 0.125 µg/mL | [142] | |
Label-free | -- | Pyrene | Fluorescence emission shift | serum | 200 pM | [143] | |
Covalent | 6-carboxyfluorescein | -- | Fluorescence anisotropy increase | saliva | 4.9 nM | [144] | |
Covalent | 6-carboxyfluorescein | -- | Signal-ON | buffer solution | 0.80 µg/mL | [145] |
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Share and Cite
Musumeci, D.; Platella, C.; Riccardi, C.; Moccia, F.; Montesarchio, D. Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics. Cancers 2017, 9, 174. https://doi.org/10.3390/cancers9120174
Musumeci D, Platella C, Riccardi C, Moccia F, Montesarchio D. Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics. Cancers. 2017; 9(12):174. https://doi.org/10.3390/cancers9120174
Chicago/Turabian StyleMusumeci, Domenica, Chiara Platella, Claudia Riccardi, Federica Moccia, and Daniela Montesarchio. 2017. "Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics" Cancers 9, no. 12: 174. https://doi.org/10.3390/cancers9120174