Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes

Lidskog, Anna; Li, Yutang; Wärnmark, Kenneth

doi:10.3390/catal10060705

Open AccessReview

Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes

by

Anna Lidskog

^†

,

Yutang Li

^†

and

Kenneth Wärnmark

^*

Centre for Analysis and Synthesis, Lund University, P.O Box 124, SE-22100 Lund, Sweden

^*

Author to whom correspondence should be addressed.

^†

These authors equally contributed to this work.

Catalysts 2020, 10(6), 705; https://doi.org/10.3390/catal10060705

Submission received: 4 June 2020 / Revised: 16 June 2020 / Accepted: 18 June 2020 / Published: 23 June 2020

(This article belongs to the Special Issue New Trends in Asymmetric Catalysis)

Download

Browse Figures

Versions Notes

Abstract

The asymmetric ring-opening of epoxides is an important reaction in organic synthesis, since it allows for the enantioselective installation of two vicinal functional groups with specific stereochemistry within one step from a highly available starting material. An effective class of catalysts for the asymmetric ring-opening of epoxides is metal–salen complexes. This review summarizes the development of metal–salen catalyzed enantioselective desymmetrization of meso-epoxides and kinetic resolution of epoxides with various nucleophiles, including the design and application of both homogeneous- and heterogeneous epoxide-opening catalysts as well as multi-metallic covalent and supramolecular catalytic systems.

Keywords: asymmetric catalysis; salen complexes; ring-opening; epoxide; kinetic resolution

Graphical Abstract

Share and Cite

MDPI and ACS Style

Lidskog, A.; Li, Y.; Wärnmark, K. Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes. Catalysts 2020, 10, 705. https://doi.org/10.3390/catal10060705

AMA Style

Lidskog A, Li Y, Wärnmark K. Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes. Catalysts. 2020; 10(6):705. https://doi.org/10.3390/catal10060705

Chicago/Turabian Style

Lidskog, Anna, Yutang Li, and Kenneth Wärnmark. 2020. "Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes" Catalysts 10, no. 6: 705. https://doi.org/10.3390/catal10060705

APA Style

Lidskog, A., Li, Y., & Wärnmark, K. (2020). Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes. Catalysts, 10(6), 705. https://doi.org/10.3390/catal10060705

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI