Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Synthesis of NpFe3O4
2.3. NIPAM Polymerization on NpFe3O4 in Presence CS (Fe3O4@PNIPAM-CS)
2.4. Characterization
2.5. Vincristine Sulfate Loading
2.6. Vincristine Sulfate Release Study Mathematical Release Model
3. Results
3.1. Swelling Kinetics and LCST
3.2. Infrared Spectroscopy Analysis
3.3. Magnetic Properties
3.4. ζ-Potential
3.5. Morphology Analysis
3.6. Drug Loading (DL) and Encapsulation Efficiency (%EE)
3.7. Effect of Temperature on Drug Delivery
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Temperature (°C) | K1 | N | R2 |
---|---|---|---|
25 | 0.1168 | 0.2749 | 0.9754 |
37 | 0.0447 | 0.3929 | 0.9781 |
41 | 0.0985 | 0.3035 | 0.8911 |
Temperature (°C) | A1 | A2 | Logx01 | Logx02 | h1 | h2 | R2 |
---|---|---|---|---|---|---|---|
25 | - | - | - | - | - | - | - |
37 | −9.7686 | 0.9931 | −526.4825 | 1304.0414 | 0.0037 | 0.0037 | 0.99639 |
41 | −66.5933 | 0.9977 | −619.7001 | 715.7139 | 0.1503 | 0.1503 | 0.99853 |
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Hernández-Téllez, C.N.; Luque-Alcaraz, A.G.; Plascencia-Jatomea, M.; Higuera-Valenzuela, H.J.; Burgos-Hernández, M.; García-Flores, N.; Álvarez-Ramos, M.E.; Iriqui-Razcon, J.L.; Gonzalez, R.E.; Hernández-Abril, P.A. Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery. Polymers 2021, 13, 1704. https://doi.org/10.3390/polym13111704
Hernández-Téllez CN, Luque-Alcaraz AG, Plascencia-Jatomea M, Higuera-Valenzuela HJ, Burgos-Hernández M, García-Flores N, Álvarez-Ramos ME, Iriqui-Razcon JL, Gonzalez RE, Hernández-Abril PA. Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery. Polymers. 2021; 13(11):1704. https://doi.org/10.3390/polym13111704
Chicago/Turabian StyleHernández-Téllez, Cynthia N., Ana G. Luque-Alcaraz, Maribel Plascencia-Jatomea, Hiram J. Higuera-Valenzuela, Mabeth Burgos-Hernández, Nadia García-Flores, Mario E. Álvarez-Ramos, Jorge L. Iriqui-Razcon, Reynaldo Esquivel Gonzalez, and Pedro A. Hernández-Abril. 2021. "Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery" Polymers 13, no. 11: 1704. https://doi.org/10.3390/polym13111704