Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos

Kumar, Vijay; Goutam, Ravi Shankar; Park, Soochul; Lee, Unjoo; Kim, Jaebong

doi:10.3390/cells10082148

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Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos

by

Vijay Kumar

¹

,

Ravi Shankar Goutam

¹

,

Soochul Park

²,

Unjoo Lee

³ and

Jaebong Kim

^1,*

¹

Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Korea

²

Department of Biological Sciences, Sookmyung Women’s University, Seoul 04310, Korea

³

Department of Electrical Engineering, Hallym University, Chuncheon 24252, Korea

^*

Author to whom correspondence should be addressed.

Cells 2021, 10(8), 2148; https://doi.org/10.3390/cells10082148

Submission received: 1 July 2021 / Revised: 10 August 2021 / Accepted: 18 August 2021 / Published: 20 August 2021

(This article belongs to the Collection Fibroblast Growth Factors: Pathophysiology and Therapeutics)

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Abstract

Fibroblast growth factors (FGFs) comprise a large family of growth factors, regulating diverse biological processes including cell proliferation, migration, and differentiation. Each FGF binds to a set of FGF receptors to initiate certain intracellular signaling molecules. Accumulated evidence suggests that in early development and adult state of vertebrates, FGFs also play exclusive and context dependent roles. Although FGFs have been the focus of research for therapeutic approaches in cancer, cardiovascular disease, and metabolic syndrome, in this review, we mainly focused on their role in germ layer specification and axis patterning during early vertebrate embryogenesis. We discussed the functional roles of FGFs and their interacting partners as part of the gene regulatory network for germ layer specification, dorsal–ventral (DV), and anterior-posterior (AP) patterning. Finally, we briefly reviewed the regulatory molecules and pharmacological agents discovered that may allow modulation of FGF signaling in research.

Keywords: FGF; FGFR; embryonic development; germ layer formation; transcription regulation; embryonic patterning

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MDPI and ACS Style

Kumar, V.; Goutam, R.S.; Park, S.; Lee, U.; Kim, J. Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos. Cells 2021, 10, 2148. https://doi.org/10.3390/cells10082148

AMA Style

Kumar V, Goutam RS, Park S, Lee U, Kim J. Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos. Cells. 2021; 10(8):2148. https://doi.org/10.3390/cells10082148

Chicago/Turabian Style

Kumar, Vijay, Ravi Shankar Goutam, Soochul Park, Unjoo Lee, and Jaebong Kim. 2021. "Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos" Cells 10, no. 8: 2148. https://doi.org/10.3390/cells10082148

APA Style

Kumar, V., Goutam, R. S., Park, S., Lee, U., & Kim, J. (2021). Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos. Cells, 10(8), 2148. https://doi.org/10.3390/cells10082148

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos

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