The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease

Yanshree,; Yu, Wing Shan; Fung, Man Lung; Lee, Chi Wai; Lim, Lee Wei; Wong, Kah Hui

doi:10.3390/cells11152284

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The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease

by

Yanshree

^1,†

,

Wing Shan Yu

^1,†,

Man Lung Fung

¹,

Chi Wai Lee

¹

,

Lee Wei Lim

^1,*

and

Kah Hui Wong

^1,2,*

¹

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

²

Department of Anatomy, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Cells 2022, 11(15), 2284; https://doi.org/10.3390/cells11152284

Submission received: 18 June 2022 / Revised: 15 July 2022 / Accepted: 19 July 2022 / Published: 24 July 2022

(This article belongs to the Special Issue Current Approaches of Molecular and Biobehavioral Studies on Neuro-Psychiatric Diseases)

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder, and no effective treatments are available to treat this disorder. Therefore, researchers have been investigating Hericium erinaceus, or the monkey head mushroom, an edible medicinal mushroom, as a possible treatment for AD. In this narrative review, we evaluated six preclinical and three clinical studies of the therapeutic effects of Hericium erinaceus on AD. Preclinical trials have successfully demonstrated that extracts and bioactive compounds of Hericium erinaceus have potential beneficial effects in ameliorating cognitive functioning and behavioral deficits in animal models of AD. A limited number of clinical studies have been conducted and several clinical trials are ongoing, which have thus far shown analogous outcomes to the preclinical studies. Nonetheless, future research on Hericium erinaceus needs to focus on elucidating the specific neuroprotective mechanisms and the target sites in AD. Additionally, standardized treatment parameters and universal regulatory systems need to be established to further ensure treatment safety and efficacy. In conclusion, Hericium erinaceus has therapeutic potential and may facilitate memory enhancement in patients with AD.

Keywords: Hericium erinaceus; Alzheimer’s disease; aging; memory; preclinical; clinical

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MDPI and ACS Style

Yanshree; Yu, W.S.; Fung, M.L.; Lee, C.W.; Lim, L.W.; Wong, K.H. The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease. Cells 2022, 11, 2284. https://doi.org/10.3390/cells11152284

AMA Style

Yanshree, Yu WS, Fung ML, Lee CW, Lim LW, Wong KH. The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease. Cells. 2022; 11(15):2284. https://doi.org/10.3390/cells11152284

Chicago/Turabian Style

Yanshree, Wing Shan Yu, Man Lung Fung, Chi Wai Lee, Lee Wei Lim, and Kah Hui Wong. 2022. "The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease" Cells 11, no. 15: 2284. https://doi.org/10.3390/cells11152284

APA Style

Yanshree, Yu, W. S., Fung, M. L., Lee, C. W., Lim, L. W., & Wong, K. H. (2022). The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease. Cells, 11(15), 2284. https://doi.org/10.3390/cells11152284

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease

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