LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features
Abstract
:1. Introduction
2. Gene Description and Encoded Proteins
3. Regulation of LIM Kinases—Partner Network
3.1. LIMKs, Downstream Effectors of Small Rho GTPases
3.2. Other Activators of LIMKs
3.3. Negative Regulators of LIMKs
3.4. Other Partners of LIMKs
4. LIMK Substrates
5. LIMK Physiological Functions
5.1. Cell Migration
5.2. Cell Cycle
5.3. Apoptosis
5.4. Neurodevelopment and Synaptic Plasticity
5.5. Membrane Trafficking
6. Involvement of LIMKs in Different Pathologies
6.1. Cancer
6.1.1. Breast Cancer
6.1.2. Prostate Cancer
6.1.3. Leukaemia
6.1.4. Osteosarcoma
6.1.5. Glioblastoma
6.2. Neuronal Diseases
6.2.1. Alzheimer’s Disease
6.2.2. Parkinson’s Disease
6.2.3. Autism Spectrum Disorders
6.2.4. Schizophrenia
6.2.5. Williams–Beuren Syndrome
6.2.6. Amyotrophic Lateral Sclerosis
6.3. Neurofibromatosis
6.3.1. Neurofibromatosis Type 1
6.3.2. Neurofibromatosis Type 2
6.4. Viral Infections
6.5. Reproduction Troubles
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Villalonga, E.; Mosrin, C.; Normand, T.; Girardin, C.; Serrano, A.; Žunar, B.; Doudeau, M.; Godin, F.; Bénédetti, H.; Vallée, B. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells 2023, 12, 805. https://doi.org/10.3390/cells12050805
Villalonga E, Mosrin C, Normand T, Girardin C, Serrano A, Žunar B, Doudeau M, Godin F, Bénédetti H, Vallée B. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells. 2023; 12(5):805. https://doi.org/10.3390/cells12050805
Chicago/Turabian StyleVillalonga, Elodie, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, Bojan Žunar, Michel Doudeau, Fabienne Godin, Hélène Bénédetti, and Béatrice Vallée. 2023. "LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features" Cells 12, no. 5: 805. https://doi.org/10.3390/cells12050805