Molecular Signature of Long Non-Coding RNA Associated with Areca Nut-Induced Head and Neck Cancer
, Guo-Rung You 2, Shang-Ju Tang 2, Joseph T. Chang 3,4,* and Ann-Joy Cheng 1,2,3,*Round 1
Reviewer 1 Report
Please find the attachment.
Comments for author File: 
Comments.pdf
Author Response
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Author Response File: Author Response.pdf
Reviewer 2 Report
Dear Editor,
This is an interesting title and manuscript and authors investigated systemic strategy to identify lncRNA signatures related to areca nut-induced head and neck cancer. There are some comments which should be followed before next steps;
-It would be better to explain the aim clearly.
- Introduction is poor about head and neck cancer and I suggest you the below references:
-Hajmohammadi E, Ghahremanie S, Alam M, Abbasi K, Mohamadian F, Khayatan D, Rahbar M. Biomarkers and common oral cancers: Clinical trial studies. JBUON. 2021;26(6):2227-37.
-https://pubmed.ncbi.nlm.nih.gov/34486685/ (https://www.europeanreview.org/article/26522)
-https://pubmed.ncbi.nlm.nih.gov/32135187/ (https://doi.org/10.1016/j.lfs.2020.117483)
-https://www.sciencedirect.com/science/article/abs/pii/S0014299920307494 (https://doi.org/10.1016/j.ejphar.2020.173657)
- Method and materials sections are ok and well categorized.
-Results are ok and understandable
- It would be better to present the figure 7 in results
- It would be better to explain more about HNC in first part of discussion and use the above mentioned references.
Best regards,
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
The authors addressed all the concerns and changed the manuscript accordingly. The revised version is significantly better and I recommend that this can be accepted for publication.
Reviewer 2 Report
Dear Editor,
The revised manuscript is acceptable.
Best regards,
