Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells
Abstract
:1. Introduction
2. Organization of the MYH9 Gene, MHCII-A Protein and NMII-A Hexamer
3. Clinical Features of MYH9-RD Patients
3.1. Macrothrombocytopenia
3.2. Non-Syndromic Sensorineural Deafness
3.3. Nephritis
3.4. Presenile Cataracts
3.5. Other Manifestations of MYH-RD
4. Prevalent MYH9 Genotypes
5. Regulation of NMII-A Activity
5.1. Regulation of the Conforzmation of NMII-A and Its ATPase Activity
5.2. Regulation of Bipolar Filament Formation and Higher Order Mini-Filament Assembly and Disassembly
6. Three Hypotheses to Explain the Correlation between Genotype and Molecular Phenotype
6.1. A Continuum of MYH9 Mutations that Cause Graded Molecular Defects
6.2. A Continuum of MYH9 Mutations that Causes Graded Protein Accumulation in Aggregates
6.3. Heterodimerization and Copolymerization with Different Myosin Isoforms
7. Why do MYH9-RD Patients Display Few, but Giant, Platelets?
8. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
ATP | adenosine triphosphate |
MYH9-RD | MYH9-gene Related Diseases |
MHCII | myosin heavy chain |
NMII | non-muscle myosin II |
SMM | smooth muscle myosin |
ELC | essential light chain |
RLC | regulatory light chain |
NHT | non-helical tailpiece |
ACD | assembly-competent domain |
CXCL12 | chemokine CXCL12, also known as stromal cell-derived factor-1 (SDF-1) |
MK | megakaryocyte |
DFNA | Deafness, Autosomal Dominant |
ROCK | RhoA- Coiled Coil Kinase |
PKC | protein kinase C |
TRPM7 | transient receptor potential melastatin 7 |
CKII | casein kinase II |
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Asensio-Juárez, G.; Llorente-González, C.; Vicente-Manzanares, M. Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells. Cells 2020, 9, 1458. https://doi.org/10.3390/cells9061458
Asensio-Juárez G, Llorente-González C, Vicente-Manzanares M. Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells. Cells. 2020; 9(6):1458. https://doi.org/10.3390/cells9061458
Chicago/Turabian StyleAsensio-Juárez, Gloria, Clara Llorente-González, and Miguel Vicente-Manzanares. 2020. "Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells" Cells 9, no. 6: 1458. https://doi.org/10.3390/cells9061458