Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders

Paul, Sujay; Bravo Vázquez, Luis Alberto; Pérez Uribe, Samantha; Roxana Reyes-Pérez, Paula; Sharma, Ashutosh

doi:10.3390/cells9071698

Open AccessReview

Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders

by

Sujay Paul

^*

,

Luis Alberto Bravo Vázquez

^†

,

Samantha Pérez Uribe

^†,

Paula Roxana Reyes-Pérez

^†

and

Ashutosh Sharma

^*

Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Querétaro CP 76130, Mexico

^*

Authors to whom correspondence should be addressed.

^†

These authors have contributed equally to this work.

Cells 2020, 9(7), 1698; https://doi.org/10.3390/cells9071698

Submission received: 1 June 2020 / Revised: 3 July 2020 / Accepted: 3 July 2020 / Published: 15 July 2020

(This article belongs to the Special Issue microRNA as Therapeutic Target)

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Abstract

MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological and pathological mechanisms in the human system. In recent years, plenty of miRNAs have been identified to be involved in the development of neurodegenerative disorders (NDDs), thus making them an attractive option for therapeutic approaches. Hence, in this review, we provide an overview of the current research of miRNA-based therapeutics for a selected set of NDDs, either for their high prevalence or lethality, such as Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis, Friedreich’s Ataxia, Spinal Muscular Atrophy, and Frontotemporal Dementia. We also discuss the relevant delivery techniques, pertinent outcomes, their limitations, and their potential to become a new generation of human therapeutic drugs in the near future.

Keywords: MicroRNA; neurodegenerative disorders; miRNA therapeutics; miRNA delivery

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MDPI and ACS Style

Paul, S.; Bravo Vázquez, L.A.; Pérez Uribe, S.; Roxana Reyes-Pérez, P.; Sharma, A. Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders. Cells 2020, 9, 1698. https://doi.org/10.3390/cells9071698

AMA Style

Paul S, Bravo Vázquez LA, Pérez Uribe S, Roxana Reyes-Pérez P, Sharma A. Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders. Cells. 2020; 9(7):1698. https://doi.org/10.3390/cells9071698

Chicago/Turabian Style

Paul, Sujay, Luis Alberto Bravo Vázquez, Samantha Pérez Uribe, Paula Roxana Reyes-Pérez, and Ashutosh Sharma. 2020. "Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders" Cells 9, no. 7: 1698. https://doi.org/10.3390/cells9071698

APA Style

Paul, S., Bravo Vázquez, L. A., Pérez Uribe, S., Roxana Reyes-Pérez, P., & Sharma, A. (2020). Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders. Cells, 9(7), 1698. https://doi.org/10.3390/cells9071698

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders

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