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Volume 15
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10.3390/genes15010114
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Communication

Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis

by
Nathan Kinsey
1,
Janelle M. Belanger
1,
Paul J. J. Mandigers
2,
Peter A. Leegwater
2,
Tiina Heinonen
3,4,5,
Marjo K. Hytönen
3,4,5,
Hannes Lohi
3,4,5,
Elaine A. Ostrander
6 and
Anita M. Oberbauer
1,*
1
Department of Animal Science, University of California, Davis, CA 95616, USA
2
Department of Clinical Sciences, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands
3
Department of Medical and Clinical Genetics, University of Helsinki, 00014 Helsinki, Finland
4
Department of Veterinary Biosciences, University of Helsinki, 00014 Helsinki, Finland
5
Folkhälsan Research Center, 00290 Helsinki, Finland
6
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Genes 2024, 15(1), 114; https://doi.org/10.3390/genes15010114
Submission received: 20 December 2023 / Revised: 11 January 2024 / Accepted: 17 January 2024 / Published: 18 January 2024
(This article belongs to the Special Issue Companion Animal Genetics and Genomics)
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Abstract

Idiopathic epilepsy (IE) has been known to be inherited in the Belgian Tervuren for many decades. Risk genotypes for IE in this breed have recently been identified on Canis familiaris chromosomes (CFA) 14 and 37. In the current study, the allele frequencies of these loci were analyzed to determine whether dog breeders had employed a purposeful selection against IE, leading to a reduction in risk-associated allele frequency within the breed over time. The allele frequencies of two generational groupings of Belgian Tervuren with and without IE were compared. Allele frequencies for risk-associated alleles on CFA14 were unchanged between 1985 and 2015, whereas those on CFA37 increased during that time in the control population (p < 0.05). In contrast, dogs with IE showed a decrease (p < 0.05) in the IE risk-associated allele frequency at the CFA37 locus. Seizure prevalence in the Belgian Tervuren appears to be increasing. These results suggest that, despite awareness that IE is inherited, selection against IE has not been successful.
Keywords: idiopathic epilepsy; seizure; Belgian Tervuren; selective breeding; neurological disorder; dog idiopathic epilepsy; seizure; Belgian Tervuren; selective breeding; neurological disorder; dog

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MDPI and ACS Style

Kinsey, N.; Belanger, J.M.; Mandigers, P.J.J.; Leegwater, P.A.; Heinonen, T.; Hytönen, M.K.; Lohi, H.; Ostrander, E.A.; Oberbauer, A.M. Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis. Genes 2024, 15, 114. https://doi.org/10.3390/genes15010114

AMA Style

Kinsey N, Belanger JM, Mandigers PJJ, Leegwater PA, Heinonen T, Hytönen MK, Lohi H, Ostrander EA, Oberbauer AM. Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis. Genes. 2024; 15(1):114. https://doi.org/10.3390/genes15010114

Chicago/Turabian Style

Kinsey, Nathan, Janelle M. Belanger, Paul J. J. Mandigers, Peter A. Leegwater, Tiina Heinonen, Marjo K. Hytönen, Hannes Lohi, Elaine A. Ostrander, and Anita M. Oberbauer. 2024. "Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis" Genes 15, no. 1: 114. https://doi.org/10.3390/genes15010114

APA Style

Kinsey, N., Belanger, J. M., Mandigers, P. J. J., Leegwater, P. A., Heinonen, T., Hytönen, M. K., Lohi, H., Ostrander, E. A., & Oberbauer, A. M. (2024). Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis. Genes, 15(1), 114. https://doi.org/10.3390/genes15010114

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