The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification
Abstract
:1. Introduction
1.1. Ether Lipids and Their Biosynthesis
1.2. The AGMO Reaction
1.3. Structural Features of the AGMO Protein
2. Alkylglycerols
2.1. Occurrence and Properties of Alkylglycerols
2.2. Dietary Supplementation of Alkylglycerols
2.3. Interdependence of Ether Lipid and Sphingolipid Metabolism
2.4. Analytics of Ether Lipids
2.5. Discrimination of 1-O-Alkyl- and 1-O-Alk-1′-Enyl-Lipids
3. AGMO in Human Diseases
3.1. Genome-Wide Association Studies
3.2. Mutations, Copy Number Variations, and Deletions in the AGMO Gene
3.2.1. Autism Spectrum Disorders
3.2.2. Microcephaly
3.2.3. Neurodevelopmental Disorders
3.2.4. Inflammation
3.2.5. Heterotaxy
4. AGMO in Model Organisms
4.1. Mouse (Mus Musculus)
4.1.1. AGMO in Macrophage Polarisation
4.1.2. AGMO in Experimental Colitis
4.1.3. Mouse Models Deficient in the AGMO Cofactor Tetrahydrobiopterin
4.2. The Nematode Caenorhabditis Elegans
4.2.1. Importance of AGMO for Cuticle Stability
4.2.2. Role of AGMO in Insulin-Like Signalling
4.3. The Clawed Frog Xenopus tropicalis
4.4. Chicken (Gallus Gallus)
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Sailer, S.; Keller, M.A.; Werner, E.R.; Watschinger, K. The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification. Life 2021, 11, 88. https://doi.org/10.3390/life11020088
Sailer S, Keller MA, Werner ER, Watschinger K. The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification. Life. 2021; 11(2):88. https://doi.org/10.3390/life11020088
Chicago/Turabian StyleSailer, Sabrina, Markus A. Keller, Ernst R. Werner, and Katrin Watschinger. 2021. "The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification" Life 11, no. 2: 88. https://doi.org/10.3390/life11020088