Hypoxia is a current research topic in biology, physiology, and medicine. The effects of hypoxia and the adaptive and maladaptive responses to the hypoxic stress are extensively explored in the domains of altitude, exercise, pulmonary and cardiovascular medicine, inflammation, immunity, cancer, and metabolic diseases. However, the molecular machinery that regulates the activity of certain genes in response to hypoxia is still not explored. This Special Issue “Cellular and Functional Response to Hypoxia” presents 14 papers dealing with all aspects of responses to hypoxia, at the molecular, cellular, and integrative levels [1,2,3]. First, cellular signaling in hypoxia is addressed. Then, ventilatory, cardiovascular, and hematological responses are explored, with special attention on the effects of exercise in hypoxia. Finally, the effects of altitude on some cardiovascular and pulmonary diseases are presented. Altogether, this volume offers a large spectrum of current research on the effects of altitude hypoxia in the fields of health and disease. Thank you again to all contributors for this Special Issue of Life.
Funding
This research received no external funding.
Conflicts of Interest
The author declares no conflict of interest.
References
- Hermand, E.; Lhuissier, F.J.; Pichon, A.; Voituron, N.; Richalet, J.-P. Exercising in Hypoxia and Other Stimuli: Heart Rate Variability and Ventilatory Oscillations. Life 2021, 11, 625. [Google Scholar] [CrossRef] [PubMed]
- Serebrovska, Z.O.; Xi, L.; Tumanovska, L.V.; Shysh, A.M.; Goncharov, S.V.; Khetsuriani, M.; Kozak, T.O.; Pashevin, D.A.; Dosenko, V.E.; Virko, S.V.; et al. Response of Circulating Inflammatory Markers to Intermittent Hypoxia-Hyperoxia Training in Healthy Elderly People and Patients with Mild Cognitive Impairment. Life 2022, 12, 432. [Google Scholar] [CrossRef] [PubMed]
- O’Brien, K.A.; Murray, A.J.; Simonson, T.S. Notch Signaling and Cross-Talk in Hy-poxia: A Candidate Pathway for High-Altitude Adaptation. Life 2022, 12, 437. [Google Scholar] [CrossRef] [PubMed]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2022 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).