Repeated Glutathione Sodium Salt Infusion May Counteract Contrast-Associated Acute Kidney Injury Occurrence in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Randomized Subgroup Analysis of the GSH 2014 Trial
Abstract
:1. Introduction
2. Methods
3. Statistical Analysis
4. Results
5. Discussion
6. Limitations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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CA-AKI | No CA-AKI | p | |
---|---|---|---|
N, | 24 | 76 | |
Male sex, % | 65 | 73 | 0.50 |
Age, years | 69 (10) | 68 (11) | 0.78 |
BMI, kg/m2 | 25.1 (4) | 26.8 (4) | 0.11 |
T2DM, % | 37 | 38 | 0.94 |
Peak troponin, ng/mL | 193 [102–200] | 178 [178–207] | 0.66 |
Door to balloon, hh:mm | 4:40 (1:35) | 3:57 (1:23) | 0.06 |
Baseline eGFR, mL/min/1.73 m2 | 86 [66–93] | 81 [66–94] | 0.66 |
Contrast volume/eGFR ratio, | 2.68 [2.31–3.04] | 2.64 [2.22–3.31] | 0.84 |
Anterior STEMI, n (%) | 8 (33) | 34 (45) | 0.32 |
Killip class ≥ 3, n (%) | 2 (9) | 3 (4) | 0.40 |
Atrial fibrillation, n (%) | 2 (8) | 9 (12) | 0.63 |
Previous PCI, n (%) | 2 (8) | 3 (4) | 0.40 |
N. of stents, | 1.2 (0.3) | 1.2 (0.4) | 0.95 |
Procedural time, min | 54 (15) | 54 (13) | 0.98 |
Statin use, n (%) | 13 (54) | 34 (45) | 0.49 |
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Arrivi, A.; Pucci, G.; Sordi, M.; Dominici, M.; Barillà, F.; Carnevale, R.; Morgantini, A.; Rosati, R.; Mangieri, E.; Tanzilli, G. Repeated Glutathione Sodium Salt Infusion May Counteract Contrast-Associated Acute Kidney Injury Occurrence in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Randomized Subgroup Analysis of the GSH 2014 Trial. Life 2023, 13, 1391. https://doi.org/10.3390/life13061391
Arrivi A, Pucci G, Sordi M, Dominici M, Barillà F, Carnevale R, Morgantini A, Rosati R, Mangieri E, Tanzilli G. Repeated Glutathione Sodium Salt Infusion May Counteract Contrast-Associated Acute Kidney Injury Occurrence in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Randomized Subgroup Analysis of the GSH 2014 Trial. Life. 2023; 13(6):1391. https://doi.org/10.3390/life13061391
Chicago/Turabian StyleArrivi, Alessio, Giacomo Pucci, Martina Sordi, Marcello Dominici, Francesco Barillà, Roberto Carnevale, Amalia Morgantini, Riccardo Rosati, Enrico Mangieri, and Gaetano Tanzilli. 2023. "Repeated Glutathione Sodium Salt Infusion May Counteract Contrast-Associated Acute Kidney Injury Occurrence in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Randomized Subgroup Analysis of the GSH 2014 Trial" Life 13, no. 6: 1391. https://doi.org/10.3390/life13061391