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Life
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Mechanisms of Injury and Repair during Acute Kidney Injury
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Mechanisms of Injury and Repair during Acute Kidney Injury

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3299

Special Issue Editor

Dr. Subhashini Bolisetty

E-Mail Website
Guest Editor
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Interests: acute kidney injury; repair; mechanisms; signaling; nephrotoxins; fibrosis; kidney function; kidney damage

Special Issue Information

Dear Colleagues,

Acute kidney injury (AKI) is a common clinical condition associated with diverse etiologies. We have made remarkable advances in the past few decades to identify biomarkers that aid in the early diagnosis of AKI. We have also made seminal contributions to the field by elucidating the role of multiple cell types (renal and extra-renal) that mediate responses to injury. It is now clear that these responses are timely, dynamic and potentiate cross-talk signaling that ultimately determines the fate of the kidney. However, we still have a huge knowledge gap in the identification of molecular and cross-talk signaling mechanisms that mediate an adaptative or maladaptive response to an acute insult. Furthermore, it is evident that AKI can increase the susceptibility to developing chronic kidney disease.

Therefore, in this Special Issue, “Mechanisms of Injury and Repair during Acute Kidney Injury”, we will unravel the complex molecular mechanisms that regulate kidney injury and mediate repair.

Dr. Subhashini Bolisetty
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute kidney injury
  • repair mechanisms
  • cross-talk signalling
  • nephrotoxins
  • fibrosis
  • kidney function
  • kidney damage

Published Papers (2 papers)

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Research

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10 pages, 898 KiB  
Article
Recovery of Renal Function in Clinical Patients with Acute Kidney Injury: Impact on Mortality
by Tayse Tâmara Paixão Duarte and Marcia Cristina Silva Magro
Life 2022, 12(6), 852; https://doi.org/10.3390/life12060852 - 8 Jun 2022
Cited by 1 | Viewed by 1892
Abstract
Objective: To assess the different renal function recovery patterns and their impact on the mortality of non-critical patients with hospital-acquired Acute Kidney Injury. Design: A prospective cohort study was conducted from January 2017 to December 2019. Methods: The patients included were those with [...] Read more.
Objective: To assess the different renal function recovery patterns and their impact on the mortality of non-critical patients with hospital-acquired Acute Kidney Injury. Design: A prospective cohort study was conducted from January 2017 to December 2019. Methods: The patients included were those with Acute Kidney Injury acquired during their hospitalization, identified from Kidney Disease: Improving Global Outcomes (KDIGO). Renal function recovery was calculated through the serum creatinine ratio in relation to baseline creatinine at the renal function evaluation moment. A descriptive analysis of the results was performed, and the Backward method was adopted for the multivariate analysis. Results: One-thousand five-hundred and forty-six patients were evaluated in the medical clinic and 202 (13.06%) were identified to have Acute Kidney Injury; among them, renal function recovery varied over the six months of follow-up with greater expressiveness in the second and third months (from 61.02% to 62.79%). Recovery was a protective factor against in-hospital death in the first (OR 0.24; 95% CI 0.09–0.61; p-value = 0.038) and sixth month of follow-up (OR 0.24; 95% CI 0.09–0.61; p-value = 0.003). Conclusions: The incidence of renal function recovery varied throughout the six months of follow-up and reached progressively high levels from the second to the third months. Renal recovery was a protective factor against mortality during the follow-up period. Full article
(This article belongs to the Special Issue Mechanisms of Injury and Repair during Acute Kidney Injury)
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7 pages, 551 KiB  
Brief Report
Repeated Glutathione Sodium Salt Infusion May Counteract Contrast-Associated Acute Kidney Injury Occurrence in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Randomized Subgroup Analysis of the GSH 2014 Trial
by Alessio Arrivi, Giacomo Pucci, Martina Sordi, Marcello Dominici, Francesco Barillà, Roberto Carnevale, Amalia Morgantini, Riccardo Rosati, Enrico Mangieri and Gaetano Tanzilli
Life 2023, 13(6), 1391; https://doi.org/10.3390/life13061391 - 14 Jun 2023
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Abstract
Background: Contrast-associated acute kidney injury (CA-AKI) is still a major concern for referring physicians, especially in the setting of ST-elevation myocardial infarction (STEMI) patients undergoing primary-PCI (pPCI). To evaluate whether glutathione sodium salt (GSS) infusion impacts favorably on CA-AKI, an unplanned exploratory data [...] Read more.
Background: Contrast-associated acute kidney injury (CA-AKI) is still a major concern for referring physicians, especially in the setting of ST-elevation myocardial infarction (STEMI) patients undergoing primary-PCI (pPCI). To evaluate whether glutathione sodium salt (GSS) infusion impacts favorably on CA-AKI, an unplanned exploratory data analysis of the GSH 2014 trial was performed. Methods: One hundred patients with STEMI were assigned at random to an experimental group (No. 50) or to a placebo group (No. 50). Treatment consisted of an intravenous infusion of GSS lasting over 10 min before p-PCI. The placebo group received the same quantity of normal saline solution. After the interventions, glutathione was administered in the same doses to both groups at 24, 48 and 72 h. Results: CA-AKI occurred in 5 out of 50 patients (10%) allocated to the experimental group (GSS infusion) and in 19 out of 50 patients (38%) allocated to the placebo group (p between groups < 0.001). No patients in either group required renal replacement therapy. After allowing for multiple confounders, GSS administration (OR 0.17, 95% CI 0.04–0.61) and door-to-balloon time (in hours) (OR 1.61, 95% CI 1.01–2.58) have been the only independent predictors of CA-AKI. Conclusions: the results of this sub-study, which show a significant trend towards an improved nephroprotection in the experimental group, led to the hypothesis of a possible new prophylactic approach to counteract CA-AKI using repeated GSS infusion. Subsequent studies with specific clinical outcomes would be necessary to confirm these data. Full article
(This article belongs to the Special Issue Mechanisms of Injury and Repair during Acute Kidney Injury)
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