Matrisome Transcriptome Dynamics during Tissue Aging
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tissue/Organ | Female | Male | ||||||
---|---|---|---|---|---|---|---|---|
Upregulated | Downregulated | Upregulated | Downregulated | |||||
C | MA | C | MA | C | MA | C | MA | |
Blood | 29 | 99 | 17 | 79 | 33 | 129 | 27 | 98 |
Heart | 27 | 21 | 0 | 15 | 43 | 87 | 10 | 50 |
Brain | 19 | 35 | 6 | 25 | 7 | 19 | 13 | 25 |
Liver | 8 | 23 | 7 | 36 | 4 | 15 | 16 | 55 |
Kidneys | 0 | 15 | 1 | 8 | 11 | 26 | 10 | 18 |
Lung | 78 | 99 | 7 | 49 | 106 | 194 | 10 | 107 |
Muscle | 54 | 84 | 4 | 34 | 106 | 164 | 19 | 38 |
Upregulated | Downregulated | ||||
---|---|---|---|---|---|
Tissue/Organ | Category | Female | Male | Female | Male |
Blood | collagens | COL6A2 | COL6A2 | COL9A3 COL7A1 | COL9A3 COL7A1 COL9A2 COL18A1 |
ECM glycoproteins | FGG FGB FGA SPP1 SPON2 THBS1 LTBP4 COLQ TNXB LAMB3 | FGG VWCE THBS1 FGA SPON2 FGB COLQ LTBP4 IGFBP4 LTBP3 | CRISPLD2 TNFAIP6 AEBP1 MFAP3 LRG1 FGL2 FBN2 LAMC1 THBS3 MFAP1 | TNFAIP6 CRISPLD2 PCOLCE2 LRG1 MFAP3 VWA5A EFEMP2 MFAP1 THBS3 GAS6 | |
proteoglycans | PRG2 PRG3 SPOCK2 VCAN | PRG3 PRG2 SPOCK2 VCAN | SRGN | SRGN | |
Brain | collagens | COL6A3 COL1A1 COL8A2 COL1A2 COL16A1 | COL27A1 | COL26A1 | |
ECM glycoproteins | VWA3A TINAGL1 MGP EMILIN3 LAMC3 SMOC1 LTBP2 | EMILIN1 LGI4 VWCE | NPNT SMOC2 | NELL1 LGI2 SLIT2 MFAP3 FBLN7 NTNG1 RELN | |
proteoglycans | DCN | ||||
Heart | collagens | COL14A1 COL16A1 | COL1A1 COL3A1 COL12A1 COL5A1 COL6A2 COL16A1 COL6A1 | ||
ECM glycoproteins | COMP LTBP2 EFEMP1 AEBP1 SMOC2 RELN IGFBP3 FN1 SRPX2 SNED1 | SPP1 LTBP2 IGFBP3 TNC THBS4 MXRA5 SMOC2 AEBP1 EFEMP1 SRPX2 | ADIPOQ SMOC1 THBS1 VWA7 THSD4 MFAP1 SRPX CRELD1 | ||
proteoglycans | PRG4 PRELP FMOD BGN | PRG4 ASPN FMOD BGN OMD VCAN SRGN | |||
Kidneys | collagens | COL7A1 | COL5A2 | ||
ECM glycoproteins | FGG FGB FGA LAMB3 LAMC2 VTN NTN1 | ADIPOQ | HMCN2 NELL1 LAMA1 ECM1 EFEMP2 | ||
Liver | collagens | COL7A1 COL27A1 | COL7A1 COL5A3 | COL4A1 | COL4A1 COL1A1 COL4A2 |
ECM glycoproteins | SMOC1 SPON2 IGFBP4 | LAMB3 | SPP1 LAMC1 VWA5A LAMB2 | TGFBI NTN4 CRELD1 MFAP3 LAMB2 MMRN2 MFAP1 LAMA5 | |
proteoglycans | ASPN | VCAN | PRG HSPG2 | ||
Lung | collagens | COL11A2 COL23A1 COL9A2 COL14A1 COL6A6 COL21A1 COL4A6 COL16A1 COL18A1 COL4A5 | COL6A6 COL13A1 COL16A1 COL21A1 COL7A1 COL18A1 COL23A1 COL12A1 COL11A2 COL4A1 | COL24A1 | COL6A5 COL4A4 |
ECM glycoproteins | DPT SMOC2 IGFBP6 TNFAIP6 MFAP4 AEBP1 ELN MFAP5 CRISPLD2 MGP | COMP CTHRC1 DPT TNR RSPO4 ECM2 SMOC2 AEBP1 MFAP4 NTNG2 | SPP1 VWA1 MFAP1 | LGI3 FGA DMBT1 SPP1 LRG1 LAMB3 LAMC2 NTN4 MFAP1 VWA1 | |
proteoglycans | ACAN PRG4 PRELP OMD ASPN DCN SRGN BGN PODN FMOD | ASPN ESM1 ACAN HAPLN3 PRG4 PRELP BGN SRGN PODNL1 OMD | |||
Muscle | collagens | COL21A1 COL4A6 COL4A3 COL7A1 COL8A1 COL4A5 COL6A3 | COL1A1 COL3A1 COL1A2 COL15A1 COL5A1 COL6A2 COL8A1 COL6A1 COL7A1 COL18A1 | COL5A3 | |
ECM glycoproteins | MFAP4 PCOLCE DPT NPNT SPON2 LGI4 LTBP1 FBLN2 SNED1 SLIT2 | FNDC1 THBS4 NPNT PCOLCE MFAP4 SVEP1 DPT SPON2 TNXB POSTN | MFAP3 MFAP1 | IGFBP5 MFAP3 SMOC1 MFAP1 | |
proteoglycans | CHAD LUM FMOD HAPLN3 PODN DCN SRGN | LUM CHAD ASPN BGN PODN VCAN HAPLN3 FMOD DCN SRGN |
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Guvatova, Z.G.; Kobelyatskaya, A.A.; Kudasheva, E.R.; Pudova, E.A.; Bulavkina, E.V.; Churov, A.V.; Tkacheva, O.N.; Moskalev, A.A. Matrisome Transcriptome Dynamics during Tissue Aging. Life 2024, 14, 593. https://doi.org/10.3390/life14050593
Guvatova ZG, Kobelyatskaya AA, Kudasheva ER, Pudova EA, Bulavkina EV, Churov AV, Tkacheva ON, Moskalev AA. Matrisome Transcriptome Dynamics during Tissue Aging. Life. 2024; 14(5):593. https://doi.org/10.3390/life14050593
Chicago/Turabian StyleGuvatova, Zulfiya G., Anastasiya A. Kobelyatskaya, Eveline R. Kudasheva, Elena A. Pudova, Elizaveta V. Bulavkina, Alexey V. Churov, Olga N. Tkacheva, and Alexey A. Moskalev. 2024. "Matrisome Transcriptome Dynamics during Tissue Aging" Life 14, no. 5: 593. https://doi.org/10.3390/life14050593