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Review

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

by
Muhammad Ali
1,2,
Viviana Benfante
1,2,*,
Domenico Di Raimondo
2,
Riccardo Laudicella
3,
Antonino Tuttolomondo
2 and
Albert Comelli
1,4
1
Ri.MED Foundation, Via Bandiera 11, 90133 Palermo, Italy
2
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Molecular and Clinical Medicine, University of Palermo, 90127 Palermo, Italy
3
Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Messina University, 98124 Messina, Italy
4
NBFC—National Biodiversity Future Center, 90133 Palermo, Italy
*
Author to whom correspondence should be addressed.
Life 2024, 14(6), 751; https://doi.org/10.3390/life14060751
Submission received: 22 April 2024 / Revised: 24 May 2024 / Accepted: 7 June 2024 / Published: 12 June 2024
(This article belongs to the Section Radiobiology and Nuclear Medicine)
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Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disorder caused by inflammation of cartilaginous diarthrodial joints that destroys joints and cartilage, resulting in synovitis and pannus formation. Timely detection and effective management of RA are pivotal for mitigating inflammatory arthritis consequences, potentially influencing disease progression. Nuclear medicine using radiolabeled targeted vectors presents a promising avenue for RA diagnosis and response to treatment assessment. Radiopharmaceutical such as technetium-99m (99mTc), combined with single photon emission computed tomography (SPECT) combined with CT (SPECT/CT), introduces a more refined diagnostic approach, enhancing accuracy through precise anatomical localization, representing a notable advancement in hybrid molecular imaging for RA evaluation. This comprehensive review discusses existing research, encompassing in vitro, in vivo, and clinical studies to explore the application of 99mTc radiolabeled targeting vectors with SPECT imaging for RA diagnosis. The purpose of this review is to highlight the potential of this strategy to enhance patient outcomes by improving the early detection and management of RA.
Keywords: 99mTc; autoimmune disorder; computed tomography; nuclear medicine; RA; radiopharmaceuticals; scintigraphy; single-photon emission computed tomography; SPECT/CT; synovitis 99mTc; autoimmune disorder; computed tomography; nuclear medicine; RA; radiopharmaceuticals; scintigraphy; single-photon emission computed tomography; SPECT/CT; synovitis

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MDPI and ACS Style

Ali, M.; Benfante, V.; Di Raimondo, D.; Laudicella, R.; Tuttolomondo, A.; Comelli, A. A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m. Life 2024, 14, 751. https://doi.org/10.3390/life14060751

AMA Style

Ali M, Benfante V, Di Raimondo D, Laudicella R, Tuttolomondo A, Comelli A. A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m. Life. 2024; 14(6):751. https://doi.org/10.3390/life14060751

Chicago/Turabian Style

Ali, Muhammad, Viviana Benfante, Domenico Di Raimondo, Riccardo Laudicella, Antonino Tuttolomondo, and Albert Comelli. 2024. "A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m" Life 14, no. 6: 751. https://doi.org/10.3390/life14060751

APA Style

Ali, M., Benfante, V., Di Raimondo, D., Laudicella, R., Tuttolomondo, A., & Comelli, A. (2024). A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m. Life, 14(6), 751. https://doi.org/10.3390/life14060751

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